Seroatlas · Human Serome Atlas

NAA50

N-alpha-acetyltransferase 50

Also known as: FLJ13194, MAK3, NAA50_HUMAN, NAT13, NAT5, San

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZZ1
Gene: NAA50
Ensembl: ENSG00000121579
Chromosome: 3
Canonical length: 169 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables histone H4 acetyltransferase activity and protein-N-terminal amino-acid acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; establishment of mitotic sister chromatid cohesion; and mitotic sister chromatid cohesion, centromeric. Located in cytosol and nucleolus. Part of NatA complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q9GZZ1|NAA50
     1  MKGSRIELGD VTPHNIKQLK RLNQVIFPVS YNDKFYKDVL EVGELAKLAY FNDIAVGAVC
    61  CRVDHSQNQK RLYIMTLGCL APYRRLGIGT KMLNHVLNIC EKDGTFDNIY LHVQISNESA
   121  IDFYRKFGFE IIETKKNYYK RIEPADAHVL QKNLKVPSGQ NADVQKTDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 259 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 259 nTPM
tongue: 114 nTPM
esophagus: 71 nTPM
bone marrow: 66 nTPM
tonsil: 65 nTPM
adipose tissue: 65 nTPM

Single-cell type

myonuclei: 355 nCPM
esophageal apical cells: 295 nCPM
basal keratinocytes: 212 nCPM
suprabasal keratinocytes: 208 nCPM
erythrocyte progenitors: 193 nCPM
neutrophils: 191 nCPM

Immune cell

memory B-cell: 52 nTPM
total PBMC: 50 nTPM
neutrophil: 48 nTPM
gdT-cell: 43 nTPM
myeloid DC: 42 nTPM
classical monocyte: 39 nTPM

Brain region

cerebral cortex: 70 nTPM
white matter: 69 nTPM
thalamus: 68 nTPM
choroid plexus: 67 nTPM
pons: 65 nTPM
spinal cord: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.73
gnomAD missense Z: 1.78
DepMap mean gene effect: -1.69
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

GNAT domain
Acyl-CoA N-acyltransferase
Acetyltransferase (GNAT) family
N-terminal and lysine N-acetyltransferase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAA50 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA50 as an antibody target. Whether an autoantibody or antibody against NAA50 could matter depends on whether native NAA50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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