Seroatlas · Human Serome Atlas

NAT8

N-acetyltransferase 8

Also known as: ATase2, GLA, Hcml1, NAT8_HUMAN, TSC501

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHE5
Gene: NAT8
Ensembl: ENSG00000144035
Chromosome: 2
Canonical length: 227 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q9UHE5|NAT8
     1  MAPCHIRKYQ ESDRQWVVGL LSRGMAEHAP ATFRQLLKLP RTLILLLGGP LALLLVSGSW
    61  LLALVFSISL FPALWFLAKK PWTEYVDMTL CTDMSDITKS YLSERGSCFW VAESEEKVVG
   121  MVGALPVDDP TLREKRLQLF HLFVDSEHRR QGIAKALVRT VLQFARDQGY SEVILDTGTI
   181  QLSAMALYQS MGFKKTGQSF FCVWARLVAL HTVHFIYHLP SSKVGSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 683 nTPM

Expression across tissuesHPA

Tissue

kidney: 683 nTPM
liver: 77 nTPM
small intestine: 6.8 nTPM
duodenum: 4.4 nTPM
retina: 1.9 nTPM
ovary: 1.2 nTPM

Single-cell type

epididymal efferent duct absorptive cells: 200 nCPM
hepatocytes: 59 nCPM
enterocytes: 56 nCPM
proximal tubule cells: 29 nCPM
epididymal efferent duct ciliated cells: 14 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 6.3 nTPM
hypothalamus: 6.1 nTPM
hippocampal formation: 5.7 nTPM
white matter: 5.6 nTPM
amygdala: 5.4 nTPM
cerebral cortex: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.57
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
N-acetyltransferase activity
protein-lysine-acetyltransferase activity
L-cysteine-S-conjugate N-acetyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAT8 as an antibody target. Whether an autoantibody or antibody against NAT8 could matter depends on whether native NAT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAT8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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