Seroatlas · Human Serome Atlas

NATD1

Protein NATD1

Also known as: C17orf103, Gtlf3b, MGC33894, NATD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6N6
Gene
NATD1
Ensembl
ENSG00000274180
Chromosome
17
Canonical length
113 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for NATD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q8N6N6|NATD1
     1  MAHSAAAVPL GALEQGCPIR VEHDRRRRQF TVRLNGCHDR AVLLYEYVGK RIVDLQHTEV
    61  PDAYRGRGIA KHLAKAALDF VVEEDLKAHL TCWYIQKYVK ENPLPQYLER LQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NATD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 38 nTPM
  • bone marrow: 18 nTPM
  • tongue: 18 nTPM
  • adipose tissue: 14 nTPM
  • heart muscle: 12 nTPM
  • thyroid gland: 9.5 nTPM

Single-cell type

  • late spermatids: 77 nCPM
  • early spermatids: 57 nCPM
  • neutrophils: 55 nCPM
  • erythrocytes: 51 nCPM
  • endometrial glandular cells: 30 nCPM
  • late primary spermatocytes: 17 nCPM

Immune cell

  • neutrophil: 5.2 nTPM
  • eosinophil: 1.5 nTPM
  • classical monocyte: 1.3 nTPM
  • total PBMC: 0.8 nTPM
  • basophil: 0.7 nTPM
  • T-reg: 0.7 nTPM

Brain region

  • cerebellum: 13 nTPM
  • medulla oblongata: 13 nTPM
  • choroid plexus: 12 nTPM
  • thalamus: 11 nTPM
  • amygdala: 11 nTPM
  • basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0.65

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Acyl-CoA N-acyltransferase
  • Yjdj-type Gcn5-related N-acetyltransferase
  • Gcn5-related N-acetyltransferase
  • GCN5-related N-acetyl-transferase

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NATD1 as an antibody target. Whether an autoantibody or antibody against NATD1 could matter depends on whether native NATD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NATD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NATD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NATD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...