NAA20

Protein identityUniProt · HPA

UniProt accession

P61599

Gene

NAA20

Ensembl

ENSG00000173418

Chromosome

20

Canonical length

178 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>P61599|NAA20
     1  MTTLRAFTCD DLFRFNNINL DPLTETYGIP FYLQYLAHWP EYFIVAEAPG GELMGYIMGK
    61  AEGSVAREEW HGHVTALSVA PEFRRLGLAA KLMELLEEIS ERKGGFFVDL FVRVSNQVAV
   121  NMYKQLGYSV YRTVIEYYSA SNGEPDEDAY DMRKALSRDT EKKSIIPLPH PVRPEDIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

173 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAA20.

Disease | AllUniProt

Conditions NAA20 is implicated in, by any mechanism.

• Intellectual developmental disorder, autosomal recessive 73 (MRT73) MIM:619717

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 28 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual developmental disorder, autosomal recessive 73

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.03

gnomAD pLI

0.01

gnomAD missense Z

1.31

DepMap mean gene effect

-0.84

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• N-terminal peptidyl-aspartic acid acetylation
• N-terminal peptidyl-glutamic acid acetylation
• N-terminal protein amino acid acetylation
• regulation of actin cytoskeleton organization
• N-terminal peptidyl-glutamine acetylation

Molecular functions

• protein N-terminal-methionine acetyltransferase activity
• protein-N-terminal amino-acid acetyltransferase activity

Cellular components

• cytoplasm
• cytosol
• NatB complex
• nucleus

Protein domainsUniProt · Pfam · InterPro

• GNAT domain
• Acyl-CoA N-acyltransferase
• Acetyltransferase (GNAT) family
• N-terminal NatB acetyltransferase catalytic subunit

KeywordsUniProt

• Acyltransferase
• Cytoplasm
• Intellectual disability
• Nucleus
• Transferase

InteractionsUniProt · HPA

Protein binding partners of NAA20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NAA25