Seroatlas · Human Serome Atlas

NAA10

N-alpha-acetyltransferase 10

Also known as: ARD1, ARD1A, DXS707, NAA10_HUMAN, TE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41227
Gene
NAA10
Ensembl
ENSG00000102030
Chromosome
X
Canonical length
235 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>P41227|NAA10
     1  MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDENG KIVGYVLAKM
    61  EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRAALH
   121  LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LTQMADELRR HLELKEKGRH VVLGAIENKV
   181  ESKGNSPPSS GEACREEKGL AAEDSGGDSK DLSEVSETTE STDVKDSSEA SDSAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 97 nTPM
  • heart muscle: 55 nTPM
  • pancreas: 45 nTPM
  • esophagus: 40 nTPM
  • adrenal gland: 39 nTPM
  • adipose tissue: 37 nTPM

Single-cell type

  • megakaryocytes: 93 nCPM
  • decidual stromal cells: 89 nCPM
  • extravillous trophoblasts: 79 nCPM
  • breast myoepithelial cells: 62 nCPM
  • migrating cytotrophoblasts: 61 nCPM
  • parietal cells: 58 nCPM

Immune cell

  • T-reg: 103 nTPM
  • eosinophil: 82 nTPM
  • MAIT T-cell: 78 nTPM
  • naive B-cell: 78 nTPM
  • non-classical monocyte: 76 nTPM
  • plasmacytoid DC: 76 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • thalamus: 17 nTPM
  • hypothalamus: 17 nTPM
  • medulla oblongata: 15 nTPM
  • pons: 15 nTPM
  • spinal cord: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAA10.

Disease | AllUniProt

Conditions NAA10 is implicated in, by any mechanism.

  • N-terminal acetyltransferase deficiency (NATD) MIM:300855
  • Microphthalmia, syndromic, 1 (MCOPS1) MIM:309800

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 241 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.76
gnomAD missense Z
2.41
DepMap mean gene effect
-0.98
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • protein maturation
  • negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric
  • positive regulation of protein refolding

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAA10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA10 as an antibody target. Whether an autoantibody or antibody against NAA10 could matter depends on whether native NAA10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAA10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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