NAT8B
N-acetyltransferase 8B
Also known as: NAT8B_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- Q9UHF3
- Gene
- NAT8B
- Canonical length
- 227 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
No narrative summary is available for NAT8B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
227 residues, UniProt reviewed canonical sequence.
>Q9UHF3|NAT8B
1 MAPYHIRKYQ ESDRKSVVGL LSGGMAEHAP ATFRRLLKLP RTLILLLGGA LALLLVSGSW
61 ILALVFSLSL LPALWFLAKK PWTRYVDIAL RTDMSDITKS YLSECGSCFW VAESEEKVVG
121 TVGALPVDDP TLREKRLQLF HLSVDNEHRG QGIAKALVRT VLQFARDQGY SEVVLDTSNI
181 QLSAMGLYQS LGFKKTGQSF FHVWARLVDL HTVHFIYHLP SAQAGRLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NAT8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 46 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 46 nTPM
- kidney: 33 nTPM
- small intestine: 30 nTPM
- colon: 2.4 nTPM
- gallbladder: 1.6 nTPM
- stomach: 1.6 nTPM
Single-cell type
- platelets: 397 nCPM
- enterocytes: 127 nCPM
- megakaryocytes: 99 nCPM
- epididymal efferent duct absorptive cells: 68 nCPM
- kupffer cells: 11 nCPM
- enteric transient amplifying cells: 8 nCPM
Immune cell
- total PBMC: 2.6 nTPM
- neutrophil: 1.1 nTPM
- myeloid DC: 0.4 nTPM
- classical monocyte: 0.3 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- medulla oblongata: 2.6 nTPM
- basal ganglia: 2.5 nTPM
- pons: 2.5 nTPM
- hypothalamus: 2.4 nTPM
- amygdala: 2.3 nTPM
- cerebral cortex: 2.1 nTPM
OntologyGO
Biological processes
- amyloid fibril formation
- amyloid-beta metabolic process
- gastrulation with mouth forming second
- negative regulation of apoptotic process
- peptidyl-lysine N6-acetylation
- positive regulation of gene expression
- regulation of macroautophagy
- regulation of reticulophagy
Molecular functions
- L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
- N-acetyltransferase activity
- protein-lysine-acetyltransferase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NAT8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NAT8B as an antibody target. Whether an autoantibody or antibody against NAT8B could matter depends on whether native NAT8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NAT8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NAT8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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