NMT2

Protein identityUniProt · HPA

UniProt accession

O60551

Gene

NMT2

Ensembl

ENSG00000152465

Chromosome

10

Canonical length

498 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>O60551|NMT2
     1  MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN
    61  SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ
   121  FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE
   181  NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS
   241  VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH
   301  RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK
   361  QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA
   421  AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL
   481  YNWRCPGTDS EKVGLVLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

25 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.24

gnomAD missense Z

1.61

DepMap mean gene effect

0.15

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular transport of virus
• N-terminal peptidyl-glycine N-myristoylation
• protein localization to membrane
• regulation of opsin-mediated signaling pathway

Molecular functions

• glycylpeptide N-tetradecanoyltransferase activity
• peptidyl-lysine N6-myristoyltransferase activity

Cellular components

• cytoplasm
• cytosol
• Golgi apparatus
• host cell
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Glycylpeptide N-tetradecanoyltransferase
• Acyl-CoA N-acyltransferase
• Glycylpeptide N-tetradecanoyltransferase, N-terminal
• Glycylpeptide N-tetradecanoyltransferase, C-terminal
• Glycylpeptide N-tetradecanoyltransferase, conserved site
• Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
• Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

KeywordsUniProt

• Acyltransferase
• Cytoplasm
• Membrane
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of NMT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ACBD6
• CSNK2A1
• CSNK2B