NAA60

Protein identityUniProt · HPA

UniProt accession

Q9H7X0

Gene

NAA60

Ensembl

ENSG00000122390

Chromosome

16

Canonical length

242 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Actin filaments,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q9H7X0|NAA60
     1  MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK KFFSLAATYR
    61  GAIVGMIVAE IKNRTKIHKE DGDILASNFS VDTQVAYILS LGVVKEFRKH GIGSLLLESL
   121  KDHISTTAQD HCKAIYLHVL TTNNTAINFY ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY
   181  INGGHPPWTI LDYIQHLGSA LASLSPCSIP HRVYRQAHSL LCSFLPWSGI SSKSGIEYSR
   241  TM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA60 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

59 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAA60.

Disease | AllUniProt

Conditions NAA60 is implicated in, by any mechanism.

• Basal ganglia calcification, idiopathic, 9, autosomal recessive (IBGC9) MIM:620786

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Basal ganglia calcification, idiopathic, 9, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.6

gnomAD pLI

0.52

gnomAD missense Z

0.93

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell population proliferation
• chromosome segregation
• N-terminal protein amino acid acetylation
• nucleosome assembly
• N-terminal peptidyl-methionine acetylation

Molecular functions

• histone acetyltransferase activity
• histone H4 acetyltransferase activity
• protein homodimerization activity
• protein N-terminal-methionine acetyltransferase activity
• protein-N-terminal amino-acid acetyltransferase activity

Cellular components

• Golgi membrane

Protein domainsUniProt · Pfam · InterPro

• GNAT domain
• Acyl-CoA N-acyltransferase
• Acetyltransferase (GNAT) family
• N-alpha-acetyltransferase 60-like

KeywordsUniProt

• Acetylation
• Acyltransferase
• Alternative promoter usage
• Chromatin regulator
• Chromosome partition
• Golgi apparatus
• Membrane
• Transferase