OAZ2

Protein identityUniProt · HPA

UniProt accession

O95190

Gene

OAZ2

Ensembl

ENSG00000180304

Chromosome

15

Canonical length

189 aa

Protein class

Predicted intracellular proteins

Subcellular location

Golgi apparatus

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>O95190|OAZ2
     1  MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD
    61  EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL
   121  ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP
   181  LDQNLSDED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OAZ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

195 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.76

gnomAD pLI

0.31

gnomAD missense Z

1.27

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of polyamine transmembrane transport
• polyamine biosynthetic process
• polyamine metabolic process
• positive regulation of intracellular protein transport
• positive regulation of protein catabolic process
• viral translational frameshifting

Molecular functions

• ornithine decarboxylase inhibitor activity

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Ornithine decarboxylase antizyme
• Acyl-CoA N-acyltransferase
• Ornithine decarboxylase antizyme superfamily
• Ornithine decarboxylase antizyme

KeywordsUniProt

• Nucleus
• Phosphoprotein
• Polyamine biosynthesis
• Ribosomal frameshifting

InteractionsUniProt · HPA

Protein binding partners of OAZ2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AZIN2
• ODC1
• AZIN1