Seroatlas · Human Serome Atlas

GLYATL1B

Putative glycine N-acyltransferase-like protein 1B

Also known as: GLYATL1P3, GLYLB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0U1RQE8
Gene: GLYATL1B
Ensembl: ENSG00000255151
Chromosome: 11
Canonical length: 302 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable glutamine N-acyltransferase activity. Predicted to be involved in glutamine metabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>A0A0U1RQE8|GLYATL1B
     1  MILLNNSERL LALFKSLARS IPESLKVYGS LFHINHGNPF NMEVLVDSWP EYQMVIIRPQ
    61  KQEMTDDMDS YTNVYRVFSK DPQKSQEVLK NSEIINWKQK LQIQGFQESL GEGIRAAAFS
   121  NSVKVEHSRA LLFVTEDILK LYATNKSKLG SWAETGHPDD ELESETPNFK YAQLNVSYSG
   181  LVNDNWKLGM NKRSLRYIKR CLGALPAACM LGPEGVPVSW VTMDPSCEIG MGYSVEKYRR
   241  RGNGTRLIMR CMKYLCQKNI PFYGSVLEEN QGVIRKTSAL GFLEASCQWH QWNCYPQNLV
   301  PL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLYATL1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 6.8 nTPM

Expression across tissuesHPA

Tissue

breast: 6.8 nTPM
lymph node: 2.6 nTPM
appendix: 0.8 nTPM
prostate: 0.7 nTPM
spleen: 0.5 nTPM
salivary gland: 0.2 nTPM

Single-cell type

b-cells: 1.9 nCPM
basal prostatic cells: 0.3 nCPM
macrophages: 0.2 nCPM
megakaryocyte-erythroid progenitors: 0.2 nCPM
neutrophils: 0.2 nCPM
prostatic glandular cells: 0.2 nCPM

Immune cell

naive B-cell: 1.5 nTPM
memory B-cell: 0.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
pons: 0.2 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

OntologyGO

Biological processes

glutamine metabolic process

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLYATL1B as an antibody target. Whether an autoantibody or antibody against GLYATL1B could matter depends on whether native GLYATL1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLYATL1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLYATL1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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