Seroatlas · Human Serome Atlas

GLYATL2

Glycine N-acyltransferase-like protein 2

Also known as: BXMAS2-10, GLYL2_HUMAN, MGC24009

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WU03
Gene
GLYATL2
Ensembl
ENSG00000156689
Chromosome
11
Canonical length
294 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables glycine N-acyltransferase activity. Involved in long-chain fatty acid catabolic process; medium-chain fatty acid catabolic process; and monounsaturated fatty acid catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q8WU03|GLYATL2
     1  MLVLHNSQKL QILYKSLEKS IPESIKVYGA IFNIKDKNPF NMEVLVDAWP DYQIVITRPQ
    61  KQEMKDDQDH YTNTYHIFTK APDKLEEVLS YSNVISWEQT LQIQGCQEGL DEAIRKVATS
   121  KSVQVDYMKT ILFIPELPKK HKTSSNDKME LFEVDDDNKE GNFSNMFLDA SHAGLVNEHW
   181  AFGKNERSLK YIERCLQDFL GFGVLGPEGQ LVSWIVMEQS CELRMGYTVP KYRHQGNMLQ
   241  IGYHLEKYLS QKEIPFYFHV ADNNEKSLQA LNNLGFKICP CGWHQWKCTP KKYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLYATL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 34 nTPM
  • cervix: 19 nTPM
  • breast: 11 nTPM
  • gallbladder: 7.1 nTPM
  • spinal cord: 1.8 nTPM
  • skin: 1.3 nTPM

Single-cell type

  • breast secretory cells: 78 nCPM
  • submucosal glandular cells: 60 nCPM
  • oligodendrocyte progenitor cells: 54 nCPM
  • endometrial secretory cells: 54 nCPM
  • retinal ganglion cells: 50 nCPM
  • breast myoepithelial cells: 42 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • basophil: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 2.5 nTPM
  • spinal cord: 1.8 nTPM
  • medulla oblongata: 1.6 nTPM
  • pons: 1.5 nTPM
  • hypothalamus: 1.1 nTPM
  • cerebellum: 0.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GLYATL2.

Disease | ImmuneIEDB

Conditions an epitope on GLYATL2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
-0.47
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLYATL2 as an antibody target. Whether an autoantibody or antibody against GLYATL2 could matter depends on whether native GLYATL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLYATL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLYATL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLYATL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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