OAZ1

Protein identityUniProt · HPA

UniProt accession

P54368

Gene

OAZ1

Ensembl

ENSG00000104904

Chromosome

19

Canonical length

228 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Vesicles,Centriolar satellite

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>P54368|OAZ1
     1  MVKSSLQRIL NSHCFAREKE GDKPSATIHA SRTMPLLSLH SRGGSSSESS RVSLHCCSNP
    61  GPGPRWCSDA PHPPLKIPGG RGNSQRDHNL SANLFYSDDR LNVTEELTSN DKTRILNVQS
   121  RLTDAKRINW RTVLSGGSLY IEIPGGALPE GSKDSFAVLL EFAEEQLRAD HVFICFHKNR
   181  EDRAALLRTF SFLGFEIVRP GHPLVPKRPD ACFMAYTFER ESSGEEEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OAZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

492 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0.18

gnomAD missense Z

-0.87

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of polyamine transmembrane transport
• polyamine biosynthetic process
• positive regulation of intracellular protein transport
• positive regulation of protein catabolic process
• viral translational frameshifting

Molecular functions

• ornithine decarboxylase inhibitor activity

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Ornithine decarboxylase antizyme
• Acyl-CoA N-acyltransferase
• Ornithine decarboxylase antizyme superfamily
• Ornithine decarboxylase antizyme

KeywordsUniProt

• Polyamine biosynthesis
• Ribosomal frameshifting
• Transport

InteractionsUniProt · HPA

Protein binding partners of OAZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AZIN2
• FAM171A1
• ODC1
• AZIN1
• AGTR1