GLYAT
Glycine N-acyltransferase
Also known as: ACGNAT, GAT, GLYAT_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6IB77
- Gene
- GLYAT
- Ensembl
- ENSG00000149124
- Chromosome
- 11
- Canonical length
- 296 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
296 residues, UniProt reviewed canonical sequence.
>Q6IB77|GLYAT
1 MMLPLQGAQM LQMLEKSLRK SLPASLKVYG TVFHINHGNP FNLKAVVDKW PDFNTVVVCP
61 QEQDMTDDLD HYTNTYQIYS KDPQNCQEFL GSPELINWKQ HLQIQSSQPS LNEAIQNLAA
121 IKSFKVKQTQ RILYMAAETA KELTPFLLKS KILSPNGGKP KAINQEMFKL SSMDVTHAHL
181 VNKFWHFGGN ERSQRFIERC IQTFPTCCLL GPEGTPVCWD LMDQTGEMRM AGTLPEYRLH
241 GLVTYVIYSH AQKLGKLGFP VYSHVDYSNE AMQKMSYTLQ HVPIPRSWNQ WNCVPLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GLYAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 652 nTPM
Expression across tissuesHPA
Tissue
- liver: 652 nTPM
- kidney: 533 nTPM
- adipose tissue: 44 nTPM
- breast: 8.4 nTPM
- blood vessel: 1.1 nTPM
- salivary gland: 1.1 nTPM
Single-cell type
- hepatocytes: 569 nCPM
- proximal tubule cells: 460 nCPM
- adipocytes: 219 nCPM
- epididymal efferent duct absorptive cells: 142 nCPM
- renal connecting tubule cells: 13 nCPM
- hepatic stellate cells: 13 nCPM
Immune cell
- basophil: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 0.9 nTPM
- pons: 0.9 nTPM
- cerebellum: 0.8 nTPM
- white matter: 0.8 nTPM
- medulla oblongata: 0.7 nTPM
- amygdala: 0.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.71
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.91
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- acyl-CoA metabolic process
- glycine metabolic process
- monocarboxylic acid metabolic process
- response to toxic substance
- xenobiotic metabolic process
- benzoyl-CoA metabolic process
Molecular functions
- acyltransferase activity
- glycine N-acyltransferase activity
- glycine N-benzoyltransferase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GLYAT as an antibody target. Whether an autoantibody or antibody against GLYAT could matter depends on whether native GLYAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GLYAT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GLYAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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