Seroatlas · Human Serome Atlas

KAT14

Cysteine-rich protein 2-binding protein

Also known as: ATAC2, CRP2BP, CSR2B_HUMAN, CSRP2BP, dJ717M23.1, PRO1194

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H8E8
Gene
KAT14
Ensembl
ENSG00000149474
Chromosome
20
Canonical length
782 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

782 residues, UniProt reviewed canonical sequence.

>Q9H8E8|KAT14
     1  MDSSIHLSSL ISRHDDEATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL SHDQSGDSLN
    61  SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN FFRFTCSDCS ADGKEQYERL
   121  KLTWQQVVML AMYNLSLEGS GRQGYFRWKE DICAFIEKHW TFLLGNRKKT STWWSTVAGC
   181  LSVGSPMYFR SGAQEFGEPG WWKLVHNKPP TMKPEGEKLS ASTLKIKAAS KPTLDPIITV
   241  EGLRKRASRN PVESAMELKE KRSRTQEAKD IRRAQKEAAG FLDRSTSSTP VKFISRGRRP
   301  DVILEKGEVI DFSSLSSSDR TPLTSPSPSP SLDFSAPGTP ASHSATPSLL SEADLIPDVM
   361  PPQALFHDDD EMEGDGVIDP GMEYVPPPAG SVASGPVVGV RKKVRGPEQI KQEVESEEEK
   421  PDRMDIDSED TDSNTSLQTR AREKRKPQLE KDTKPKEPRY TPVSIYEEKL LLKRLEACPG
   481  AVAMTPEARR LKRKLIVRQA KRDRGLPLFD LDQVVNAALL LVDGIYGAKE GGISRLPAGQ
   541  ATYRTTCQDF RILDRYQTSL PSRKGFRHQT TKFLYRLVGS EDMAVDQSIV SPYTSRILKP
   601  YIRRDYETKP PKLQLLSQIR SHLHRSDPHW TPEPDAPLDY CYVRPNHIPT INSMCQEFFW
   661  PGIDLSECLQ YPDFSVVVLY KKVIIAFGFM VPDVKYNEAY ISFLFVHPEW RRAGIATFMI
   721  YHLIQTCMGK DVTLHVSASN PAMLLYQKFG FKTEEYVLDF YDKYYPLEST ECKHAFFLRL
   781  RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KAT14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 24 nTPM
  • tongue: 20 nTPM
  • stomach: 13 nTPM
  • thymus: 13 nTPM
  • parathyroid gland: 12 nTPM
  • ovary: 12 nTPM

Single-cell type

  • extravillous trophoblasts: 69 nCPM
  • migrating cytotrophoblasts: 38 nCPM
  • gonadotrophs: 28 nCPM
  • differentiating spermatogonia: 27 nCPM
  • oligodendrocytes: 27 nCPM
  • myonuclei: 26 nCPM

Immune cell

  • naive CD4 T-cell: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • non-classical monocyte: 13 nTPM
  • NK-cell: 13 nTPM
  • memory CD8 T-cell: 12 nTPM
  • naive CD8 T-cell: 12 nTPM

Brain region

  • hypothalamus: 21 nTPM
  • cerebral cortex: 20 nTPM
  • basal ganglia: 20 nTPM
  • hippocampal formation: 19 nTPM
  • white matter: 18 nTPM
  • cerebellum: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KAT14.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 35 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KAT14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KAT14 as an antibody target. Whether an autoantibody or antibody against KAT14 could matter depends on whether native KAT14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KAT14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KAT14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KAT14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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