Seroatlas · Human Serome Atlas

NAA40

N-alpha-acetyltransferase 40

Also known as: FLJ13848, NAA40_HUMAN, NAT11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UY6
Gene: NAA40
Ensembl: ENSG00000110583
Chromosome: 11
Canonical length: 237 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite,Cytosol

OverviewNCBI Gene

Enables histone H2A acetyltransferase activity; histone H4 acetyltransferase activity; and protein N-terminal-serine acetyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within lipid metabolic process. Located in centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q86UY6|NAA40
     1  MGRKSSKAKE KKQKRLEERA AMDAVCAKVD AANRLGDPLE AFPVFKKYDR NGLNVSIECK
    61  RVSGLEPATV DWAFDLTKTN MQTMYEQSEW GWKDREKREE MTDDRAWYLI AWENSSVPVA
   121  FSHFRFDVEC GDEVLYCYEV QLESKVRRKG LGKFLIQILQ LMANSTQMKK VMLTVFKHNH
   181  GAYQFFREAL QFEIDDSSPS MSGCCGEDCS YEILSRRTKF GDSHHSHAGG HCGGCCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
parathyroid gland: 14 nTPM
pituitary gland: 12 nTPM
choroid plexus: 10 nTPM
cerebellum: 10 nTPM
heart muscle: 9.3 nTPM

Single-cell type

late spermatids: 195 nCPM
retinal horizontal cells: 106 nCPM
late primary spermatocytes: 58 nCPM
cone photoreceptor cells: 50 nCPM
choroid plexus epithelial cells: 45 nCPM
early spermatids: 42 nCPM

Immune cell

gdT-cell: 6.9 nTPM
NK-cell: 5.2 nTPM
plasmacytoid DC: 3.5 nTPM
memory CD8 T-cell: 3.3 nTPM
eosinophil: 2.7 nTPM
memory B-cell: 2.7 nTPM

Brain region

choroid plexus: 7.2 nTPM
medulla oblongata: 7.1 nTPM
midbrain: 6.3 nTPM
cerebral cortex: 6.1 nTPM
pons: 6.1 nTPM
thalamus: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 1.24
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAA40 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA40 as an antibody target. Whether an autoantibody or antibody against NAA40 could matter depends on whether native NAA40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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