SAT2
Thialysine N-epsilon-acetyltransferase
Also known as: SAT2_HUMAN, SSAT2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96F10
- Gene
- SAT2
- Ensembl
- ENSG00000141504
- Chromosome
- 17
- Canonical length
- 170 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables diamine N-acetyltransferase activity and identical protein binding activity. Involved in polyamine metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
170 residues, UniProt reviewed canonical sequence.
>Q96F10|SAT2
1 MASVRIREAK EGDCGDILRL IRELAEFEKL SDQVKISEEA LRADGFGDNP FYHCLVAEIL
61 PAPGKLLGPC VVGYGIYYFI YSTWKGRTIY LEDIYVMPEY RGQGIGSKII KKVAEVALDK
121 GCSQFRLAVL DWNQRAMDLY KALGAQDLTE AEGWHFFCFQ GEATRKLAGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 131 nTPM
Expression across tissuesHPA
Tissue
- liver: 131 nTPM
- adrenal gland: 106 nTPM
- kidney: 101 nTPM
- duodenum: 87 nTPM
- small intestine: 62 nTPM
- choroid plexus: 60 nTPM
Single-cell type
- enterocytes: 968 nCPM
- hepatocytes: 328 nCPM
- cholangiocytes: 313 nCPM
- granulosa cells: 303 nCPM
- ovarian stromal cells: 303 nCPM
- epididymal efferent duct absorptive cells: 269 nCPM
Immune cell
- classical monocyte: 42 nTPM
- myeloid DC: 31 nTPM
- intermediate monocyte: 28 nTPM
- total PBMC: 23 nTPM
- T-reg: 20 nTPM
- naive CD4 T-cell: 18 nTPM
Brain region
- choroid plexus: 18 nTPM
- thalamus: 10 nTPM
- hypothalamus: 10 nTPM
- spinal cord: 9.5 nTPM
- cerebellum: 8.8 nTPM
- midbrain: 8.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.55
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.47
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- spermidine acetylation
- nor-spermidine metabolic process
- putrescine acetylation
- spermine acetylation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SAT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SAT2 as an antibody target. Whether an autoantibody or antibody against SAT2 could matter depends on whether native SAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SAT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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