HAT1

Protein identityUniProt · HPA

UniProt accession

O14929

Gene

HAT1

Ensembl

ENSG00000128708

Chromosome

2

Canonical length

419 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>O14929|HAT1
     1  MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT FFPEYTHQLF
    61  GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD CVEADDVEGK IRQIIPPGFC
   121  TNTNDFLSLL EKEVDFKPFG TLLHTYSVLS PTGGENFTFQ IYKADMTCRG FREYHERLQT
   181  FLMWFIETAS FIDVDDERWH YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ
   241  MLILTPFQGQ GHGAQLLETV HRYYTEFPTV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF
   301  SREKLMQGFN EDMVIEAQQK FKINKQHARR VYEILRLLVT DMSDAEQYRS YRLDIKRRLI
   361  SPYKKKQRDL AKMRKCLRPE ELTNQMNQIE ISMQHEQLEE SFQELVEDYR RVIERLAQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

64 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.39

gnomAD pLI

0.84

gnomAD missense Z

1.54

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromosome organization
• internal protein amino acid acetylation
• nucleosome assembly
• subtelomeric heterochromatin formation

Molecular functions

• histone acetyltransferase activity
• histone binding
• histone H4 acetyltransferase activity
• histone H4K12 acetyltransferase activity
• histone methacryltransferase activity

Cellular components

• chromatin
• chromosome, telomeric region
• mitochondrion
• nuclear matrix
• nucleoplasm
• nucleus
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Acyl-CoA N-acyltransferase
• Histone acetyltransferase HAT1, C-terminal
• Histone acetyltransferase type B, catalytic subunit
• Histone acetyl transferase HAT1 N-terminal
• Histone acetyl transferase 1, N-terminal domain superfamily
• Histone acetyltransferase type B catalytic subunit, C-terminal
• Histone acetyl transferase HAT1 N-terminus
• Histone acetyltransferase type B catalytic subunit, C-terminal

KeywordsUniProt

• Acetylation
• Acyltransferase
• Cytoplasm
• Mitochondrion
• Nucleus
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of HAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• H2A
• ASF1A
• ASF1B
• RBBP4
• RBBP7