Seroatlas · Human Serome Atlas

GLYATL1

Glycine N-acyltransferase-like protein 1

Also known as: FLJ34646, GLYL1_HUMAN, MGC15397

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969I3
Gene: GLYATL1
Ensembl: ENSG00000166840
Chromosome: 11
Canonical length: 302 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables glutamine N-acyltransferase activity. Involved in glutamine metabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>Q969I3|GLYATL1
     1  MILLNNSHKL LALYKSLARS IPESLKVYGS VYHINHGNPF NMEVLVDSWP EYQMVIIRPQ
    61  KQEMTDDMDS YTNVYRMFSK EPQKSEEVLK NCEIVNWKQR LQIQGLQESL GEGIRVATFS
   121  KSVKVEHSRA LLLVTEDILK LNASSKSKLG SWAETGHPDD EFESETPNFK YAQLDVSYSG
   181  LVNDNWKRGK NERSLHYIKR CIEDLPAACM LGPEGVPVSW VTMDPSCEVG MAYSMEKYRR
   241  TGNMARVMVR YMKYLRQKNI PFYISVLEEN EDSRRFVGQF GFFEASCEWH QWTCYPQNLV
   301  PF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLYATL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 508 nTPM

Expression across tissuesHPA

Tissue

liver: 508 nTPM
kidney: 131 nTPM
prostate: 11 nTPM
breast: 4.7 nTPM
parathyroid gland: 2.7 nTPM
stomach: 2.7 nTPM

Single-cell type

hepatocytes: 314 nCPM
proximal tubule cells: 111 nCPM
hematopoietic stem cells: 34 nCPM
platelets: 32 nCPM
prostatic glandular cells: 29 nCPM
tuft cells: 23 nCPM

Immune cell

naive B-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

pons: 2.4 nTPM
medulla oblongata: 1.6 nTPM
choroid plexus: 1.3 nTPM
cerebral cortex: 1.1 nTPM
cerebellum: 0.8 nTPM
spinal cord: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: -0.62
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

glutamine metabolic process

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLYATL1 as an antibody target. Whether an autoantibody or antibody against GLYATL1 could matter depends on whether native GLYATL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLYATL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLYATL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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