Seroatlas · Human Serome Atlas

OAZ3

Ornithine decarboxylase antizyme 3

Also known as: OAZ3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UMX2
Gene: OAZ3
Ensembl: ENSG00000143450
Chromosome: 1
Canonical length: 235 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mid piece,Principal piece
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q9UMX2|OAZ3
     1  MPCKRCRPSV YSLSYIKRGK TRNYLYPIWS PYAYYLYCYK YRITLREKML PRCYKSITYK
    61  EEEDLTLQPR SCLQCSESLV GLQEGKSTEQ GNHDQLKELY SAGNLTVLAT DPLLHQDPVQ
   121  LDFHFRLTSQ TSAHWHGLLC DRRLFLDIPY QALDQGNRES LTATLEYVEE KTNVDSVFVN
   181  FQNDRNDRGA LLRAFSYMGF EVVRPDHPAL PPLDNVIFMV YPLERDVGHL PSEPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OAZ3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 224 nTPM

Expression across tissuesHPA

Tissue

testis: 224 nTPM
prostate: 15 nTPM
salivary gland: 7.2 nTPM
parathyroid gland: 4 nTPM
thyroid gland: 3.1 nTPM
skeletal muscle: 2.8 nTPM

Single-cell type

late spermatids: 21,909 nCPM
early spermatids: 2,903 nCPM
late primary spermatocytes: 372 nCPM
breast lactating cells: 67 nCPM
cardiomyocytes: 58 nCPM
prostatic glandular cells: 30 nCPM

Immune cell

non-classical monocyte: 1.5 nTPM
myeloid DC: 0.9 nTPM
classical monocyte: 0.8 nTPM
NK-cell: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM

Brain region

cerebellum: 9.9 nTPM
pons: 7 nTPM
medulla oblongata: 6.7 nTPM
hippocampal formation: 6.5 nTPM
cerebral cortex: 6.4 nTPM
amygdala: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OAZ3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OAZ3 as an antibody target. Whether an autoantibody or antibody against OAZ3 could matter depends on whether native OAZ3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OAZ3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OAZ3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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