Seroatlas · Human Serome Atlas

KAT2A

Histone acetyltransferase KAT2A

Also known as: GCN5, GCN5L2, KAT2A_HUMAN, PCAF-b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92830
Gene
KAT2A
Ensembl
ENSG00000108773
Chromosome
17
Canonical length
837 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

Canonical amino-acid sequenceUniProt

837 residues, UniProt reviewed canonical sequence.

>Q92830|KAT2A
     1  MAEPSQAPTP APAAQPRPLQ SPAPAPTPTP APSPASAPIP TPTPAPAPAP AAAPAGSTGT
    61  GGPGVGSGGA GSGGDPARPG LSQQQRASQR KAQVRGLPRA KKLEKLGVFS ACKANETCKC
   121  NGWKNPKPPT APRMDLQQPA ANLSELCRSC EHPLADHVSH LENVSEDEIN RLLGMVVDVE
   181  NLFMSVHKEE DTDTKQVYFY LFKLLRKCIL QMTRPVVEGS LGSPPFEKPN IEQGVLNFVQ
   241  YKFSHLAPRE RQTMFELSKM FLLCLNYWKL ETPAQFRQRS QAEDVATYKV NYTRWLCYCH
   301  VPQSCDSLPR YETTHVFGRS LLRSIFTVTR RQLLEKFRVE KDKLVPEKRT LILTHFPKFL
   361  SMLEEEIYGA NSPIWESGFT MPPSEGTQLV PRPASVSAAV VPSTPIFSPS MGGGSNSSLS
   421  LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL
   481  SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA
   541  RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE
   601  YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL MECELNPRIP
   661  YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV RQIPVESVPG IRETGWKPLG
   721  KEKGKELKDP DQLYTTLKNL LAQIKSHPSA WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE
   781  RLRSRYYVTR KLFVADLQRV IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KAT2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 25 nTPM
  • cerebellum: 22 nTPM
  • adrenal gland: 18 nTPM
  • fallopian tube: 18 nTPM
  • cerebral cortex: 17 nTPM
  • cervix: 16 nTPM

Single-cell type

  • sertoli cells: 115 nCPM
  • adrenal cortex cells: 100 nCPM
  • astrocytes: 97 nCPM
  • leydig cells: 62 nCPM
  • oligodendrocyte progenitor cells: 53 nCPM
  • bergmann glia: 48 nCPM

Immune cell

  • memory CD8 T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.6 nTPM
  • memory B-cell: 0.5 nTPM
  • memory CD4 T-cell: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM
  • myeloid DC: 0.4 nTPM

Brain region

  • thalamus: 38 nTPM
  • cerebral cortex: 38 nTPM
  • hypothalamus: 35 nTPM
  • white matter: 34 nTPM
  • amygdala: 32 nTPM
  • basal ganglia: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KAT2A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 108 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.57
gnomAD missense Z
3.82
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KAT2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KAT2A as an antibody target. Whether an autoantibody or antibody against KAT2A could matter depends on whether native KAT2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KAT2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KAT2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KAT2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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