MORC3

Protein identityUniProt · HPA

UniProt accession

Q14149

Gene

MORC3

Ensembl

ENSG00000159256

Chromosome

21

Canonical length

939 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

939 residues, UniProt reviewed canonical sequence.

>Q14149|MORC3
     1  MAAQPPRGIR LSALCPKFLH TNSTSHTWPF SAVAELIDNA YDPDVNAKQI WIDKTVINDH
    61  ICLTFTDNGN GMTSDKLHKM LSFGFSDKVT MNGHVPVGLY GNGFKSGSMR LGKDAIVFTK
   121  NGESMSVGLL SQTYLEVIKA EHVVVPIVAF NKHRQMINLA ESKASLAAIL EHSLFSTEQK
   181  LLAELDAIIG KKGTRIIIWN LRSYKNATEF DFEKDKYDIR IPEDLDEITG KKGYKKQERM
   241  DQIAPESDYS LRAYCSILYL KPRMQIILRG QKVKTQLVSK SLAYIERDVY RPKFLSKTVR
   301  ITFGFNCRNK DHYGIMMYHR NRLIKAYEKV GCQLRANNMG VGVVGIIECN FLKPTHNKQD
   361  FDYTNEYRLT ITALGEKLND YWNEMKVKKN TEYPLNLPVE DIQKRPDQTW VQCDACLKWR
   421  KLPDGMDQLP EKWYCSNNPD PQFRNCEVPE EPEDEDLVHP TYEKTYKKTN KEKFRIRQPE
   481  MIPRINAELL FRPTALSTPS FSSPKESVPR RHLSEGTNSY ATRLLNNHQV PPQSEPESNS
   541  LKRRLSTRSS ILNAKNRRLS SQFENSVYKG DDDDEDVIIL EENSTPKPAV DHDIDMKSEQ
   601  SHVEQGGVQV EFVGDSEPCG QTGSTSTSSS RCDQGNTAAT QTEVPSLVVK KEETVEDEID
   661  VRNDAVILPS CVEAEAKIHE TQETTDKSAD DAGCQLQELR NQLLLVTEEK ENYKRQCHMF
   721  TDQIKVLQQR ILEMNDKYVK KETCHQSTET DAVFLLESIN GKSESPDHMV SQYQQALEEI
   781  ERLKKQCSAL QHVKAECSQC SNNESKSEMD EMAVQLDDVF RQLDKCSIER DQYKSEVELL
   841  EMEKSQIRSQ CEELKTEVEQ LKSTNQQTAT DVSTSSNIEE SVNHMDGESL KLRSLRVNVG
   901  QLLAMIVPDL DLQQVNYDVD VVDEILGQVV EQMSEISST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

33 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MORC3.

Disease | AutoantibodyPubMed

Conditions in which antibodies against MORC3 are reported. Each links to that disease's full target list.

• Dermatomyositis 61
• Myositis 29
• Lung Diseases, Interstitial 15
• Calcinosis 12
• Muscle Weakness 8
• Polymyositis 7

Showing 6 of 7 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for MORC3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.22

gnomAD pLI

1

gnomAD missense Z

2.89

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antiviral innate immune response
• maintenance of protein location in nucleus
• negative regulation of fibroblast proliferation
• negative regulation of interferon-beta production
• negative regulation of transcription by RNA polymerase II
• peptidyl-serine phosphorylation
• positive regulation of cellular senescence
• post-embryonic development
• protein phosphorylation
• protein stabilization

Molecular functions

• ATP hydrolysis activity
• DNA binding
• histone H3K4me3 reader activity
• protein-macromolecule adaptor activity
• RNA binding
• zinc ion binding

Cellular components

• chromatin
• nuclear matrix
• nucleoplasm
• nucleus
• PML body

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, CW-type
• Histidine kinase/HSP90-like ATPase superfamily
• Morc, S5 domain 2-like
• MICRORCHIDIA ATPase family
• CW-type Zinc Finger
• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
• Morc6 ribosomal protein S5 domain 2-like

KeywordsUniProt

• Chromosome
• Coiled coil
• Host-virus interaction
• Immunity
• Innate immunity
• Isopeptide bond
• Metal-binding
• Nucleus
• Phosphoprotein
• RNA-binding
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of MORC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PML
• TP53
• DYNLL1
• DYNLL2