Seroatlas · Human Serome Atlas

ANKRD2

Ankyrin repeat domain-containing protein 2

Also known as: ANKR2_HUMAN, ARPP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZV1
Gene: ANKRD2
Ensembl: ENSG00000165887
Chromosome: 10
Canonical length: 360 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q9GZV1|ANKRD2
     1  MAKAPSWAGV GALAYKAPEA LWPAEAVMDG TMEDSEAVQR ATALIEQRLA QEEENEKLRG
    61  DARQKLPMDL LVLEDEKHHG AQSAALQKVK GQERVRKTSL DLRREIIDVG GIQNLIELRK
   121  KRKQKKRDAL AASHEPPPEP EEITGPVDEE TFLKAAVEGK MKVIEKFLAD GGSADTCDQF
   181  RRTALHRASL EGHMEILEKL LDNGATVDFQ DRLDCTAMHW ACRGGHLEVV KLLQSHGADT
   241  NVRDKLLSTP LHVAVRTGQV EIVEHFLSLG LEINARDREG DTALHDAVRL NRYKIIKLLL
   301  LHGADMMTKN LAGKTPTDLV QLWQADTRHA LEHPEPGAEH NGLEGPNDSG RETPQPVPAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 1,142 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,142 nTPM
tongue: 769 nTPM
heart muscle: 496 nTPM
kidney: 18 nTPM
salivary gland: 4.1 nTPM
cerebral cortex: 3.6 nTPM

Single-cell type

myonuclei: 248 nCPM
thymic myoid cells: 143 nCPM
cardiomyocytes: 62 nCPM
alveolar cells type 1: 15 nCPM
epicardial cells: 11 nCPM
loop of henle epithelial cells: 8.2 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 5.7 nTPM
hypothalamus: 3.6 nTPM
thalamus: 3.5 nTPM
amygdala: 3.1 nTPM
cerebellum: 3.1 nTPM
medulla oblongata: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 1.15
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD2 as an antibody target. Whether an autoantibody or antibody against ANKRD2 could matter depends on whether native ANKRD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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