NUPR1
Nuclear protein 1
Also known as: COM1, NUPR1_HUMAN, p8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O60356
- Gene
- NUPR1
- Ensembl
- ENSG00000176046
- Chromosome
- 16
- Canonical length
- 82 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytokinetic bridge
OverviewNCBI Gene
Enables DNA binding activity and transcription coactivator activity. Involved in several processes, including negative regulation of programmed cell death; positive regulation of oxidative phosphorylation; and regulation of catabolic process. Acts upstream of or within negative regulation of cell cycle. Located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
82 residues, UniProt reviewed canonical sequence.
>O60356|NUPR1
1 MATFPPATSA PQQPPGPEDE DSSLDESDLY SLAHSYLGGG GRKGRTKREA AANTNRPSPG
61 GHERKLVTKL QNSERKKRGA RRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NUPR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 1,079 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 1,079 nTPM
- thyroid gland: 328 nTPM
- liver: 322 nTPM
- adrenal gland: 251 nTPM
- salivary gland: 235 nTPM
- colon: 202 nTPM
Single-cell type
- gastric chief cells: 66 nCPM
- endometrial glandular cells: 65 nCPM
- breast lactating cells: 51 nCPM
- podocytes: 50 nCPM
- lacrimal acinar cells: 49 nCPM
- bergmann glia: 47 nCPM
Immune cell
- basophil: 15 nTPM
- eosinophil: 3.7 nTPM
- neutrophil: 2.4 nTPM
- NK-cell: 0.8 nTPM
- naive B-cell: 0.5 nTPM
- plasmacytoid DC: 0.5 nTPM
Brain region
- medulla oblongata: 79 nTPM
- hypothalamus: 77 nTPM
- midbrain: 65 nTPM
- spinal cord: 64 nTPM
- pons: 62 nTPM
- white matter: 60 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.12
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- acute inflammatory response
- fibroblast apoptotic process
- fibroblast proliferation
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- male gonad development
- negative regulation of apoptotic process
- negative regulation of autophagosome assembly
- negative regulation of autophagy
- negative regulation of cardiac muscle cell apoptotic process
- negative regulation of cell cycle
- negative regulation of cell population proliferation
- negative regulation of DNA-binding transcription factor activity
- negative regulation of epithelial cell apoptotic process
- negative regulation of epithelial cell proliferation
- negative regulation of fibroblast proliferation
- negative regulation of glycolytic process
- negative regulation of programmed necrotic cell death
- negative regulation of type B pancreatic cell proliferation
- positive regulation of cell cycle
- positive regulation of fibroblast apoptotic process
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of neuroinflammatory response
- positive regulation of neuron apoptotic process
- positive regulation of oxidative phosphorylation
- positive regulation of proteasomal protein catabolic process
- protein-containing complex assembly
- regulation of autophagy
- regulation of female gonad development
- regulation of response to endoplasmic reticulum stress
- response to toxic substance
- skeletal muscle cell differentiation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NUPR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NUPR1 as an antibody target. Whether an autoantibody or antibody against NUPR1 could matter depends on whether native NUPR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NUPR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NUPR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...