Seroatlas · Human Serome Atlas

BANP

Protein BANP

Also known as: BANP_HUMAN, BEND1, DKFZp761H172, FLJ10177, FLJ20538, SMAR1, SMARBP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N9N5
Gene
BANP
Ensembl
ENSG00000172530
Chromosome
16
Canonical length
519 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q8N9N5|BANP
     1  MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD PSIKTICLRL
    61  DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS PLGATQTCNK VRCVVPQTTV
   121  ILNNDRQNAI VAKMEDPLSN RAPDSLENVI SNAVPGRRQN TIVVKVPGQE DSHHEDGESG
   181  SEASDSVSSC GQAGSQSIGS NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH
   241  ISTNCRTAEK MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT
   301  ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM STPPPASELP
   361  QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV PQGEQVQITQ DSEGNLQIHH
   421  VGQDGQLLEA TRIPCLLAPS VFKASSGQVL QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV
   481  QYVQLAPVSD HTAGAQTAEA LQPTLQPEMQ LEHGAIQIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BANP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 12 nTPM
  • liver: 9.9 nTPM
  • thymus: 9.9 nTPM
  • cerebellum: 9.4 nTPM
  • ovary: 8.9 nTPM
  • lymph node: 8.8 nTPM

Single-cell type

  • somatotrophs: 260 nCPM
  • neutrophils: 164 nCPM
  • pdcs: 162 nCPM
  • oocytes: 157 nCPM
  • lactotrophs: 142 nCPM
  • syncytiotrophoblasts: 139 nCPM

Immune cell

  • neutrophil: 63 nTPM
  • eosinophil: 40 nTPM
  • plasmacytoid DC: 30 nTPM
  • memory B-cell: 25 nTPM
  • naive CD4 T-cell: 24 nTPM
  • myeloid DC: 24 nTPM

Brain region

  • cerebellum: 39 nTPM
  • white matter: 31 nTPM
  • choroid plexus: 31 nTPM
  • medulla oblongata: 29 nTPM
  • thalamus: 29 nTPM
  • pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
2.43
DepMap mean gene effect
-0.95
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BANP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BANP as an antibody target. Whether an autoantibody or antibody against BANP could matter depends on whether native BANP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BANP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BANP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BANP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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