Seroatlas · Human Serome Atlas

CDK5

Cyclin-dependent kinase 5

Also known as: CDK5_HUMAN, PSSALRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00535
Gene
CDK5
Ensembl
ENSG00000164885
Chromosome
7
Canonical length
292 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q00535|CDK5
     1  MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH
    61  KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR
   121  NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS
   181  TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP
   241  MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 75 nTPM
  • basal ganglia: 73 nTPM
  • hippocampal formation: 64 nTPM
  • amygdala: 62 nTPM
  • hypothalamus: 49 nTPM
  • midbrain: 35 nTPM

Single-cell type

  • hofbauer cells: 46 nCPM
  • decidual stromal cells: 44 nCPM
  • cytotrophoblasts: 32 nCPM
  • esophageal suprabasal cells: 29 nCPM
  • epididymal principal cells: 29 nCPM
  • esophageal basal cells: 24 nCPM

Immune cell

  • intermediate monocyte: 46 nTPM
  • myeloid DC: 45 nTPM
  • classical monocyte: 40 nTPM
  • non-classical monocyte: 37 nTPM
  • T-reg: 32 nTPM
  • plasmacytoid DC: 27 nTPM

Brain region

  • cerebral cortex: 63 nTPM
  • hippocampal formation: 54 nTPM
  • basal ganglia: 49 nTPM
  • hypothalamus: 46 nTPM
  • white matter: 44 nTPM
  • thalamus: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK5.

Disease | AllUniProt

Conditions CDK5 is implicated in, by any mechanism.

  • Lissencephaly 7, with cerebellar hypoplasia (LIS7) MIM:616342

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 87 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.14
gnomAD missense Z
3.07
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK5 as an antibody target. Whether an autoantibody or antibody against CDK5 could matter depends on whether native CDK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK5 is annotated at the cell surface, where native CDK5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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