p53/RUNT-type transcription factor, DNA-binding domain superfamily

Definition

This DNA-binding domain superfamily is found in the p53 and the RUNT families of transcription factors. The DNA-binding domain acts to clamp or encircle the DNA target in order to stabilise the protein-DNA complex. This domain has an immunoglobulin-like fold consisting of a β-sandwich of 9 strands in two sheets with a Greek key topology PMID:10545320.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• RUNX1
• RUNX2
• RUNX3
• TP53
• TP63
• TP73