Seroatlas · Human Serome Atlas

ING4

Inhibitor of growth protein 4

Also known as: ING4_HUMAN, my036, p29ING4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNL4
Gene: ING4
Ensembl: ENSG00000111653
Chromosome: 12
Canonical length: 249 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q9UNL4|ING4
     1  MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE
    61  KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD
   121  YDSSSSKGKK KGRTQKEKKA ARARSKGKNS DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS
   181  VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP
   241  RCSQERKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ING4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 48 nTPM
spleen: 37 nTPM
ovary: 36 nTPM
thymus: 36 nTPM
spinal cord: 35 nTPM
cervix: 35 nTPM

Single-cell type

platelets: 127 nCPM
esophageal apical cells: 58 nCPM
cytotrophoblasts: 56 nCPM
epididymal principal cells: 51 nCPM
ovarian stromal cells: 51 nCPM
granulosa cells: 45 nCPM

Immune cell

non-classical monocyte: 51 nTPM
naive B-cell: 48 nTPM
intermediate monocyte: 44 nTPM
NK-cell: 38 nTPM
naive CD4 T-cell: 38 nTPM
total PBMC: 38 nTPM

Brain region

white matter: 32 nTPM
cerebellum: 25 nTPM
medulla oblongata: 24 nTPM
spinal cord: 24 nTPM
pons: 23 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.03
gnomAD missense Z: 1.81
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ING4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ING4 as an antibody target. Whether an autoantibody or antibody against ING4 could matter depends on whether native ING4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ING4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ING4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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