Seroatlas · Human Serome Atlas

CDKN2AIP

CDKN2A-interacting protein

Also known as: CARF, CARF_HUMAN, FLJ20036

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NXV6
Gene
CDKN2AIP
Ensembl
ENSG00000168564
Chromosome
4
Canonical length
580 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>Q9NXV6|CDKN2AIP
     1  MAQEVSEYLS QNPRVAAWVE ALRCDGETDK HWRHRRDFLL RNAGDLAPAG GAASASTDEA
    61  ADAESGTRNR QLQQLISFSM AWANHVFLGC RYPQKVMDKI LSMAEGIKVT DAPTYTTRDE
   121  LVAKVKKRGI SSSNEGVEEP SKKRVIEGKN SSAVEQDHAK TSAKTERASA QQENSSTCIG
   181  SAIKSESGNS ARSSGISSQN SSTSDGDRSV SSQSSSSVSS QVTTAGSGKA SEAEAPDKHG
   241  SASFVSLLKS SVNSHMTQST DSRQQSGSPK KSALEGSSAS ASQSSSEIEV PLLGSSGSSE
   301  VELPLLSSKP SSETASSGLT SKTSSEASVS SSVAKNSSSS GTSLLTPKSS SSTNTSLLTS
   361  KSTSQVAASL LASKSSSQTS GSLVSKSTSL ASVSQLASKS SSQTSTSQLP SKSTSQSSES
   421  SVKFSCKLTN EDVKQKQPFF NRLYKTVAWK LVAVGGFSPN VNHGELLNAA IEALKATLDV
   481  FFVPLKELAD LPQNKSSQES IVCELRCKSV YLGTGCGKSK ENAKAVASRE ALKLFLKKKV
   541  VVKICKRKYR GSEIEDLVLL DEESRPVNLP PALKHPQELL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKN2AIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 36 nTPM
  • thymus: 22 nTPM
  • esophagus: 21 nTPM
  • testis: 19 nTPM
  • ovary: 19 nTPM
  • lymph node: 19 nTPM

Single-cell type

  • endometrial luminal cells: 410 nCPM
  • endometrial glandular cells: 301 nCPM
  • early spermatids: 186 nCPM
  • endometrial ciliated cells: 174 nCPM
  • esophageal apical cells: 167 nCPM
  • ocular epithelial cells: 161 nCPM

Immune cell

  • basophil: 61 nTPM
  • naive CD4 T-cell: 23 nTPM
  • naive CD8 T-cell: 21 nTPM
  • T-reg: 19 nTPM
  • eosinophil: 19 nTPM
  • memory CD4 T-cell: 18 nTPM

Brain region

  • cerebellum: 18 nTPM
  • white matter: 15 nTPM
  • spinal cord: 13 nTPM
  • hypothalamus: 12 nTPM
  • basal ganglia: 12 nTPM
  • cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
0.54
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDKN2AIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDKN2AIP as an antibody target. Whether an autoantibody or antibody against CDKN2AIP could matter depends on whether native CDKN2AIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDKN2AIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDKN2AIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDKN2AIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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