Seroatlas · Human Serome Atlas

NOC2L

Nucleolar complex protein 2 homolog

Also known as: DKFZP564C186, NET15, NET7, NIR, NOC2L_HUMAN, PPP1R112

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3T9
Gene: NOC2L
Ensembl: ENSG00000188976
Chromosome: 1
Canonical length: 749 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

749 residues, UniProt reviewed canonical sequence.

>Q9Y3T9|NOC2L
     1  MAAAGSRKRR LAELTVDEFL ASGFDSESES ESENSPQAET REAREAARSP DKPGGSPSAS
    61  RRKGRASEHK DQLSRLKDRD PEFYKFLQEN DQSLLNFSDS DSSEEEEGPF HSLPDVLEEA
   121  SEEEDGAEEG EDGDRVPRGL KGKKNSVPVT VAMVERWKQA AKQRLTPKLF HEVVQAFRAA
   181  VATTRGDQES AEANKFQVTD SAAFNALVTF CIRDLIGCLQ KLLFGKVAKD SSRMLQPSSS
   241  PLWGKLRVDI KAYLGSAIQL VSCLSETTVL AAVLRHISVL VPCFLTFPKQ CRMLLKRMVI
   301  VWSTGEESLR VLAFLVLSRV CRHKKDTFLG PVLKQMYITY VRNCKFTSPG ALPFISFMQW
   361  TLTELLALEP GVAYQHAFLY IRQLAIHLRN AMTTRKKETY QSVYNWQYVH CLFLWCRVLS
   421  TAGPSEALQP LVYPLAQVII GCIKLIPTAR FYPLRMHCIR ALTLLSGSSG AFIPVLPFIL
   481  EMFQQVDFNR KPGRMSSKPI NFSVILKLSN VNLQEKAYRD GLVEQLYDLT LEYLHSQAHC
   541  IGFPELVLPV VLQLKSFLRE CKVANYCRQV QQLLGKVQEN SAYICSRRQR VSFGVSEQQA
   601  VEAWEKLTRE EGTPLTLYYS HWRKLRDREI QLEISGKERL EDLNFPEIKR RKMADRKDED
   661  RKQFKDLFDL NSSEEDDTEG FSERGILRPL STRHGVEDDE EDEEEGEEDS SNSEDGDPDA
   721  EAGLAPGELQ QLAQGPEDEL EDLQLSEDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOC2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 69 nTPM
esophagus: 46 nTPM
skin: 43 nTPM
cerebellum: 35 nTPM
testis: 34 nTPM
pancreas: 34 nTPM

Single-cell type

differentiating spermatogonia: 109 nCPM
esophageal basal cells: 107 nCPM
esophageal suprabasal cells: 102 nCPM
migrating cytotrophoblasts: 77 nCPM
cytotrophoblasts: 76 nCPM
suprabasal keratinocytes: 76 nCPM

Immune cell

non-classical monocyte: 58 nTPM
intermediate monocyte: 46 nTPM
myeloid DC: 37 nTPM
NK-cell: 35 nTPM
total PBMC: 32 nTPM
MAIT T-cell: 31 nTPM

Brain region

cerebral cortex: 34 nTPM
pons: 33 nTPM
hypothalamus: 31 nTPM
medulla oblongata: 31 nTPM
white matter: 30 nTPM
thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -1.9
DepMap mean gene effect: -0.75
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

chromosome
cytosol
nucleolus
nucleoplasm
nucleus
Noc1p-Noc2p complex
Noc2p-Noc3p complex

Protein domainsUniProt · Pfam · InterPro

Armadillo-type fold
Nucleolar complex protein 2
Noc2p family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOC2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOC2L as an antibody target. Whether an autoantibody or antibody against NOC2L could matter depends on whether native NOC2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOC2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOC2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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