Seroatlas · Human Serome Atlas

AURKA

Aurora kinase A

Also known as: AIK, ARK1, AurA, AURKA_HUMAN, BTAK, PPP1R47, STK15, STK6, STK7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14965
Gene
AURKA
Ensembl
ENSG00000087586
Chromosome
20
Canonical length
403 aa
Protein class
Cancer-related genes, Enzymes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitotic spindle,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>O14965|AURKA
     1  MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRIPLQ
    61  AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN
   121  EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR
   181  EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL
   241  ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM
   301  IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVTEGARDLI
   361  SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AURKA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • testis: 29 nTPM
  • tonsil: 21 nTPM
  • lymph node: 20 nTPM
  • thymus: 19 nTPM
  • bone marrow: 15 nTPM
  • rectum: 12 nTPM

Single-cell type

  • oocytes: 355 nCPM
  • late primary spermatocytes: 269 nCPM
  • monocyte progenitors: 90 nCPM
  • extravillous trophoblasts: 77 nCPM
  • erythrocyte progenitors: 62 nCPM
  • migrating cytotrophoblasts: 57 nCPM

Immune cell

  • intermediate monocyte: 5.9 nTPM
  • T-reg: 4.8 nTPM
  • eosinophil: 4.3 nTPM
  • myeloid DC: 3.7 nTPM
  • classical monocyte: 3.5 nTPM
  • non-classical monocyte: 3.4 nTPM

Brain region

  • cerebellum: 7.7 nTPM
  • medulla oblongata: 6.6 nTPM
  • cerebral cortex: 6.4 nTPM
  • thalamus: 6.4 nTPM
  • basal ganglia: 6.2 nTPM
  • pons: 5.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AURKA.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on AURKA was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.87
gnomAD missense Z
1.6
DepMap mean gene effect
-1.24
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AURKA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AURKA as an antibody target. Whether an autoantibody or antibody against AURKA could matter depends on whether native AURKA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AURKA is annotated at the cell surface, where native AURKA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AURKA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AURKA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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