Seroatlas · Human Serome Atlas

PPP1R13L

RelA-associated inhibitor

Also known as: IASPP, IASPP_HUMAN, RAI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUF5
Gene: PPP1R13L
Ensembl: ENSG00000104881
Chromosome: 19
Canonical length: 828 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

828 residues, UniProt reviewed canonical sequence.

>Q8WUF5|PPP1R13L
     1  MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW SDSPAPPGPQ
    61  AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS ESAPTLHPYS PLSPKGRPSS
   121  PRTPLYLQPD AYGSLDRATS PRPRAFDGAG SSLGRAPSPR PGPGPLRQQG PPTPFDFLGR
   181  AGSPRGSPLA EGPQAFFPER GPSPRPPATA YDAPASAFGS SLLGSGGSAF APPLRAQDDL
   241  TLRRRPPKAW NESDLDVAYE KKPSQTASYE RLDVFARPAS PSLQLLPWRE SSLDGLGGTG
   301  KDNLTSATLP RNYKVSPLAS DRRSDAGSYR RSLGSAGPSG TLPRSWQPVS RIPMPPSSPQ
   361  PRGAPRQRPI PLSMIFKLQN AFWEHGASRA MLPGSPLFTR APPPKLQPQP QPQPQPQSQP
   421  QPQLPPQPQT QPQTPTPAPQ HPQQTWPPVN EGPPKPPTEL EPEPEIEGLL TPVLEAGDVD
   481  EGPVARPLSP TRLQPALPPE AQSVPELEEV ARVLAEIPRP LKRRGSMEQA PAVALPPTHK
   541  KQYQQIISRL FHRHGGPGPG GPEPELSPIT EGSEARAGPP APAPPAPIPP PAPSQSSPPE
   601  QPQSMEMRSV LRKAGSPRKA RRARLNPLVL LLDAALTGEL EVVQQAVKEM NDPSQPNEEG
   661  ITALHNAICG ANYSIVDFLI TAGANVNSPD SHGWTPLHCA ASCNDTVICM ALVQHGAAIF
   721  ATTLSDGATA FEKCDPYREG YADCATYLAD VEQSMGLMNS GAVYALWDYS AEFGDELSFR
   781  EGESVTVLRR DGPEETDWWW AALHGQEGYV PRNYFGLFPR VKPQRSKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R13L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 187 nTPM

Expression across tissuesHPA

Tissue

skin: 187 nTPM
esophagus: 157 nTPM
heart muscle: 124 nTPM
vagina: 73 nTPM
cervix: 55 nTPM
salivary gland: 46 nTPM

Single-cell type

esophageal apical cells: 470 nCPM
cardiomyocytes: 259 nCPM
syncytiotrophoblasts: 248 nCPM
esophageal suprabasal cells: 231 nCPM
ocular epithelial cells: 190 nCPM
suprabasal keratinocytes: 165 nCPM

Immune cell

memory CD4 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
T-reg: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

hypothalamus: 15 nTPM
thalamus: 10 nTPM
white matter: 9.1 nTPM
cerebral cortex: 9 nTPM
medulla oblongata: 8.5 nTPM
pons: 8.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP1R13L.

Disease | AllUniProt

Conditions PPP1R13L is implicated in, by any mechanism.

Arrhythmogenic cardiomyopathy with variable ectodermal abnormalities (ARCME) MIM:620519

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 216 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Arrhythmogenic cardiomyopathy with variable ectodermal abnormalities
Primary dilated cardiomyopathy
Cardio-cutaneous syndrome
Orofacial cleft
OMIM:607463

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.03
gnomAD missense Z: 1.54
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH3 domain
Ankyrin repeat
SH3-like domain superfamily
Ankyrin repeat-containing domain superfamily
Ankyrin repeats (3 copies)
Variant SH3 domain
RelA-associated inhibitor
RelA-associated inhibitor, SH3 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R13L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R13L as an antibody target. Whether an autoantibody or antibody against PPP1R13L could matter depends on whether native PPP1R13L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R13L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R13L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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