Seroatlas · Human Serome Atlas

MORN3

MORN repeat-containing protein 3

Also known as: MORN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PF18
Gene: MORN3
Ensembl: ENSG00000139714
Chromosome: 12
Canonical length: 240 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in negative regulation of signal transduction by p53 class mediator. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q6PF18|MORN3
     1  MPVSKCPKKS ESLWKGWDRK AQRNGLRSQV YAVNGDYYVG EWKDNVKHGK GTQVWKKKGA
    61  IYEGDWKFGK RDGYGTLSLP DQQTGKCRRV YSGWWKGDKK SGYGIQFFGP KEYYEGDWCG
   121  SQRSGWGRMY YSNGDIYEGQ WENDKPNGEG MLRLKNGNRY EGCWERGMKN GAGRFFHLDH
   181  GQLFEGFWVD NMAKCGTMID FGRDEAPEPT QFPIPEVKIL DPDGVLAEAL AMFRKTEEGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 5.9 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 5.9 nTPM
testis: 4.3 nTPM
fallopian tube: 3.7 nTPM
cerebral cortex: 2.5 nTPM
hippocampal formation: 2.4 nTPM
parathyroid gland: 2.2 nTPM

Single-cell type

late spermatids: 3,253 nCPM
early spermatids: 407 nCPM
respiratory ciliated cells: 55 nCPM
ependymal cells: 53 nCPM
fallopian tube ciliated cells: 33 nCPM
late primary spermatocytes: 30 nCPM

Immune cell

basophil: 1.2 nTPM
neutrophil: 1.1 nTPM
MAIT T-cell: 0.8 nTPM
NK-cell: 0.8 nTPM
gdT-cell: 0.7 nTPM
memory CD4 T-cell: 0.7 nTPM

Brain region

choroid plexus: 10 nTPM
midbrain: 6.2 nTPM
medulla oblongata: 5.3 nTPM
hypothalamus: 5 nTPM
basal ganglia: 4.9 nTPM
cerebral cortex: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of signal transduction by p53 class mediator

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

MORN repeat
MORN repeat
MORN repeat-containing protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MORN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORN3 as an antibody target. Whether an autoantibody or antibody against MORN3 could matter depends on whether native MORN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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