Seroatlas · Human Serome Atlas

PPP2R2A

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Also known as: 2ABA_HUMAN, B55A, B55alpha, PR52A, PR55A, PR55alpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63151
Gene: PPP2R2A
Ensembl: ENSG00000221914
Chromosome: 8
Canonical length: 447 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>P63151|PPP2R2A
     1  MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE
    61  NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK
   121  LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI
   181  NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN
   241  TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM
   301  MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG
   361  SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL
   421  HTAWHPKENI IAVATTNNLY IFQDKVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2R2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

esophagus: 38 nTPM
placenta: 36 nTPM
skeletal muscle: 29 nTPM
liver: 27 nTPM
tonsil: 24 nTPM
adipose tissue: 22 nTPM

Single-cell type

esophageal apical cells: 889 nCPM
neutrophils: 738 nCPM
neutrophil progenitors: 487 nCPM
endometrial glandular cells: 484 nCPM
ocular epithelial cells: 442 nCPM
endometrial ciliated cells: 423 nCPM

Immune cell

T-reg: 1.8 nTPM
eosinophil: 1.7 nTPM
memory B-cell: 1.3 nTPM
memory CD4 T-cell: 1.1 nTPM
myeloid DC: 1.1 nTPM
naive B-cell: 1.1 nTPM

Brain region

white matter: 23 nTPM
basal ganglia: 22 nTPM
cerebral cortex: 22 nTPM
hypothalamus: 16 nTPM
spinal cord: 16 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.99
gnomAD missense Z: 3.36
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2R2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2R2A as an antibody target. Whether an autoantibody or antibody against PPP2R2A could matter depends on whether native PPP2R2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2R2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2R2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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