Seroatlas · Human Serome Atlas

GRK5

G protein-coupled receptor kinase 5

Also known as: GPRK5, GRK5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P34947
Gene
GRK5
Ensembl
ENSG00000198873
Chromosome
10
Canonical length
590 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nuclear membrane,Nuclear speckles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>P34947|GRK5
     1  MELENIVANT VLLKAREGGG GKRKGKSKKW KEILKFPHIS QCEDLRRTID RDYCSLCDKQ
    61  PIGRLLFRQF CETRPGLECY IQFLDSVAEY EVTPDEKLGE KGKEIMTKYL TPKSPVFIAQ
   121  VGQDLVSQTE EKLLQKPCKE LFSACAQSVH EYLRGEPFHE YLDSMFFDRF LQWKWLERQP
   181  VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKRLEKK RIKKRKGESM ALNEKQILEK
   241  VNSQFVVNLA YAYETKDALC LVLTIMNGGD LKFHIYNMGN PGFEEERALF YAAEILCGLE
   301  DLHRENTVYR DLKPENILLD DYGHIRISDL GLAVKIPEGD LIRGRVGTVG YMAPEVLNNQ
   361  RYGLSPDYWG LGCLIYEMIE GQSPFRGRKE KVKREEVDRR VLETEEVYSH KFSEEAKSIC
   421  KMLLTKDAKQ RLGCQEEGAA EVKRHPFFRN MNFKRLEAGM LDPPFVPDPR AVYCKDVLDI
   481  EQFSTVKGVN LDHTDDDFYS KFSTGSVSIP WQNEMIETEC FKELNVFGPN GTLPPDLNRN
   541  HPPEPPKKGL LQRLFKRQHQ NNSKSSPSSK TSFNHHINSN HVSSNSTGSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 27 nTPM
  • lung: 25 nTPM
  • parathyroid gland: 20 nTPM
  • heart muscle: 19 nTPM
  • spleen: 14 nTPM
  • adipose tissue: 14 nTPM

Single-cell type

  • tuft cells: 726 nCPM
  • fibro-adipogenic progenitors: 466 nCPM
  • pericytes: 448 nCPM
  • podocytes: 420 nCPM
  • hepatic stellate cells: 323 nCPM
  • alveolar cells type 1: 295 nCPM

Immune cell

  • naive CD4 T-cell: 4.5 nTPM
  • naive B-cell: 4 nTPM
  • T-reg: 4 nTPM
  • memory B-cell: 3.8 nTPM
  • eosinophil: 3 nTPM
  • memory CD4 T-cell: 3 nTPM

Brain region

  • hypothalamus: 8.9 nTPM
  • basal ganglia: 8.4 nTPM
  • cerebellum: 8.2 nTPM
  • cerebral cortex: 8 nTPM
  • thalamus: 7.9 nTPM
  • amygdala: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.68
gnomAD missense Z
2.16
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRK5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRK5 as an antibody target. Whether an autoantibody or antibody against GRK5 could matter depends on whether native GRK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRK5 is annotated at the cell surface, where native GRK5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GRK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRK5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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