p53-like transcription factor, DNA-binding domain superfamily
IPR008967
Definition
This domain superfamily is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis PMID:12826037; NFATC regulates the production of effector proteins involved in coordinating the immune response PMID:8990122; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth PMID:12729611; STAT-1 plays an important role in B lymphocyte growth and function PMID:12855573; and NFkappaB is involved in the inflammatory response PMID:12421671. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex PMID:11780147. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability PMID:9630226. The DNA-binding domain consists of a β-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
44 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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