Seroatlas · Human Serome Atlas

DAXX

Death domain-associated protein 6

Also known as: DAP6, DAXX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UER7
Gene: DAXX
Ensembl: ENSG00000204209
Chromosome: 6
Canonical length: 740 aa
Protein class: Cancer-related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies
Quaternary structure: Homomultimer

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

740 residues, UniProt reviewed canonical sequence.

>Q9UER7|DAXX
     1  MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS SSSGGKKCYK
    61  LENEKLFEEF LELCKMQTAD HPEVVPFLYN RQQRAHSLFL ASAEFCNILS RVLSRARSRP
   121  AKLYVYINEL CTVLKAHSAK KKLNLAPAAT TSNEPSGNNP PTHLSLDPTN AENTASQSPR
   181  TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC
   241  ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH
   301  SLGLPRQQLQ LMAQDAFRDV GIRLQERRHL DLIYNFGCHL TDDYRPGVDP ALSDPVLARR
   361  LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG TSSHSADTPE ASLDSGEGPS
   421  GMASQGCPSA SRAETDDEDD EESDEEEEEE EEEEEEEATD SEEEEDLEQM QEGQEDDEEE
   481  DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP
   541  SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV
   601  LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG
   661  KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI PSPARLSQTP HSQPPRPGTC
   721  KTSVATQCDP EEIIVLSDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAXX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

spleen: 42 nTPM
testis: 35 nTPM
skeletal muscle: 34 nTPM
adrenal gland: 32 nTPM
esophagus: 30 nTPM
blood vessel: 30 nTPM

Single-cell type

epididymal principal cells: 87 nCPM
decidual stromal cells: 60 nCPM
early primary spermatocytes: 49 nCPM
late primary spermatocytes: 40 nCPM
suprabasal keratinocytes: 40 nCPM
basal keratinocytes: 39 nCPM

Immune cell

total PBMC: 70 nTPM
NK-cell: 63 nTPM
memory CD8 T-cell: 62 nTPM
T-reg: 60 nTPM
memory B-cell: 59 nTPM
naive B-cell: 57 nTPM

Brain region

white matter: 14 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 10 nTPM
hippocampal formation: 9.9 nTPM
thalamus: 9.4 nTPM
amygdala: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.1
gnomAD missense Z: 1.49
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Daxx, N-terminal Rassf1C-interacting domain
Daxx, N-terminal domain superfamily
Daxx, histone-binding domain
Daxx, histone-binding domain superfamily
Daxx N-terminal Rassf1C-interacting domain
Death domain-associated protein 6, histone binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DAXX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAXX as an antibody target. Whether an autoantibody or antibody against DAXX could matter depends on whether native DAXX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAXX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DAXX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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