p53-like tetramerisation domain superfamily

Definition

This entry represents the tetramerisation domain of p53. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation [[cite:PMID:11420672], [cite:PMID:19815500]]. This superfamily also includes the structural-related C-terminal SARAH (Salvador-RassF-Hippo) domain found in tumor suppressors such as Serine/threonine-protein kinase 4 (human Hippo homologue, Mst), Serine/threonine-protein kinase 3, Serine/threonine-protein kinase cst-1 and Serine/threonine-protein kinase hippo, which is involved in dimerisation PMID:29519817.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• STK3
• STK4
• TP53
• TP63
• TP73