Seroatlas · Human Serome Atlas

DAZAP2

DAZ-associated protein 2

Also known as: DAZP2_HUMAN, KIAA0058

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15038
Gene
DAZAP2
Ensembl
ENSG00000183283
Chromosome
12
Canonical length
168 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>Q15038|DAZAP2
     1  MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF VHPGAATVPT
    61  MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSTVLVEGGY DAGARFGAGA
   121  TAGNIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAZAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
579 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 579 nTPM
  • kidney: 235 nTPM
  • tonsil: 226 nTPM
  • parathyroid gland: 214 nTPM
  • spleen: 211 nTPM
  • lymph node: 206 nTPM

Single-cell type

  • neutrophils: 768 nCPM
  • kupffer cells: 539 nCPM
  • esophageal apical cells: 448 nCPM
  • neutrophil progenitors: 386 nCPM
  • parietal cells: 373 nCPM
  • monocytes: 371 nCPM

Immune cell

  • total PBMC: 4,893 nTPM
  • neutrophil: 3,523 nTPM
  • eosinophil: 3,367 nTPM
  • classical monocyte: 2,151 nTPM
  • basophil: 2,029 nTPM
  • intermediate monocyte: 1,774 nTPM

Brain region

  • white matter: 210 nTPM
  • cerebellum: 186 nTPM
  • medulla oblongata: 180 nTPM
  • spinal cord: 172 nTPM
  • pons: 167 nTPM
  • hypothalamus: 166 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.36
gnomAD missense Z
0.99
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • DAZ associated protein 2
  • DAZ associated protein 2 (DAZAP2)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DAZAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAZAP2 as an antibody target. Whether an autoantibody or antibody against DAZAP2 could matter depends on whether native DAZAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAZAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DAZAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DAZAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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