Seroatlas · Human Serome Atlas

AURKB

Aurora kinase B

Also known as: Aik2, AIM-1, ARK2, AurB, AURKB_HUMAN, IPL1, PPP1R48, STK12, STK5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GD4
Gene
AURKB
Ensembl
ENSG00000178999
Chromosome
17
Canonical length
344 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Midbody

OverviewNCBI Gene

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q96GD4|AURKB
     1  MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN
    61  SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH
   121  QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI
   181  MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL
   241  PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA
   301  QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AURKB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 56 nTPM
  • bone marrow: 42 nTPM
  • lymph node: 34 nTPM
  • tonsil: 34 nTPM
  • esophagus: 18 nTPM
  • appendix: 13 nTPM

Single-cell type

  • extravillous trophoblasts: 103 nCPM
  • monocyte progenitors: 81 nCPM
  • migrating cytotrophoblasts: 77 nCPM
  • enteric transient amplifying cells: 60 nCPM
  • esophageal basal cells: 60 nCPM
  • erythrocyte progenitors: 50 nCPM

Immune cell

  • T-reg: 7.9 nTPM
  • naive B-cell: 2.5 nTPM
  • memory CD8 T-cell: 2.1 nTPM
  • memory CD4 T-cell: 1.3 nTPM
  • memory B-cell: 1.1 nTPM
  • neutrophil: 0.9 nTPM

Brain region

  • thalamus: 1.1 nTPM
  • pons: 0.9 nTPM
  • cerebellum: 0.7 nTPM
  • hypothalamus: 0.7 nTPM
  • white matter: 0.7 nTPM
  • basal ganglia: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AURKB.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 47 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on AURKB was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
gnomAD missense Z
0.74
DepMap mean gene effect
-2.3
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AURKB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AURKB as an antibody target. Whether an autoantibody or antibody against AURKB could matter depends on whether native AURKB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AURKB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AURKB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AURKB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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