ARMC10

Protein identityUniProt · HPA

UniProt accession

Q8N2F6

Gene

ARMC10

Ensembl

ENSG00000170632

Chromosome

7

Canonical length

343 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q8N2F6|ARMC10
     1  MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG
    61  RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT
   121  LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKIYIS
   181  QVCEDVFSGP LNSAVQLAGL TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK
   241  LLLNLSENPA MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ
   301  PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.1

gnomAD pLI

0

gnomAD missense Z

0.35

DepMap mean gene effect

-0.28

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of apoptotic process
• negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
• positive regulation of growth rate

Molecular functions

• DNA binding domain binding
• p53 binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• mitochondrial outer membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Armadillo repeat-containing domain
• Armadillo-like helical
• Armadillo-type fold
• Armadillo repeat-containing X-linked regulator
• Armadillo-like

KeywordsUniProt

• Endoplasmic reticulum
• Growth regulation
• Membrane
• Mitochondrion
• Mitochondrion outer membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ARMC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TP53