Seroatlas · Human Serome Atlas

CARM1

Histone-arginine methyltransferase CARM1

Also known as: CARM1_HUMAN, PRMT4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86X55
Gene
CARM1
Ensembl
ENSG00000142453
Chromosome
19
Canonical length
608 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

608 residues, UniProt reviewed canonical sequence.

>Q86X55|CARM1
     1  MAAAAAAVGP GAGGAGSAVP GGAGPCATVS VFPGARLLTI GDANGEIQRH AEQQALRLEV
    61  RAGPDSAGIA LYSHEDVCVF KCSVSRETEC SRVGKQSFII TLGCNSVLIQ FATPNDFCSF
   121  YNILKTCRGH TLERSVFSER TEESSAVQYF QFYGYLSQQQ NMMQDYVRTG TYQRAILQNH
   181  TDFKDKIVLD VGCGSGILSF FAAQAGARKI YAVEASTMAQ HAEVLVKSNN LTDRIVVIPG
   241  KVEEVSLPEQ VDIIISEPMG YMLFNERMLE SYLHAKKYLK PSGNMFPTIG DVHLAPFTDE
   301  QLYMEQFTKA NFWYQPSFHG VDLSALRGAA VDEYFRQPVV DTFDIRILMA KSVKYTVNFL
   361  EAKEGDLHRI EIPFKFHMLH SGLVHGLAFW FDVAFIGSIM TVWLSTAPTE PLTHWYQVRC
   421  LFQSPLFAKA GDTLSGTCLL IANKRQSYDI SIVAQVDQTG SKSSNLLDLK NPFFRYTGTT
   481  PSPPPGSHYT SPSENMWNTG STYNLSSGMA VAGMPTAYDL SSVIASGSSV GHNNLIPLAN
   541  TGIVNHTHSR MGSIMSTGIV QGSSGAQGSG GGSTSAHYAV NSQFTMGGPA ISMASPMSIP
   601  TNTMHYGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CARM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 104 nTPM
  • tongue: 68 nTPM
  • testis: 44 nTPM
  • esophagus: 35 nTPM
  • cerebral cortex: 33 nTPM
  • cerebellum: 31 nTPM

Single-cell type

  • retinal horizontal cells: 82 nCPM
  • myonuclei: 67 nCPM
  • cone photoreceptor cells: 58 nCPM
  • retinal bipolar cells: 55 nCPM
  • esophageal apical cells: 51 nCPM
  • erythrocyte progenitors: 50 nCPM

Immune cell

  • memory CD8 T-cell: 0.5 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM
  • memory B-cell: 0.2 nTPM
  • myeloid DC: 0.2 nTPM

Brain region

  • cerebral cortex: 38 nTPM
  • hippocampal formation: 36 nTPM
  • basal ganglia: 33 nTPM
  • white matter: 32 nTPM
  • amygdala: 30 nTPM
  • hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.1
gnomAD pLI
1
gnomAD missense Z
4.25
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CARM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CARM1 as an antibody target. Whether an autoantibody or antibody against CARM1 could matter depends on whether native CARM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CARM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CARM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CARM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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