Seroatlas · Human Serome Atlas

PDAP1

28 kDa heat- and acid-stable phosphoprotein

Also known as: HAP28_HUMAN, HASPP28, PAP, PAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13442
Gene: PDAP1
Ensembl: ENSG00000106244
Chromosome: 7
Canonical length: 181 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>Q13442|PDAP1
     1  MPKGGRKGGH KGRARQYTSP EEIDAQLQAE KQKAREEEEQ KEGGDGAAGD PKKEKKSLDS
    61  DESEDEEDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD LDGPKELSRR EREEIEKQKA
   121  KERYMKMHLA GKTEQAKADL ARLAIIRKQR EEAARKKEEE RKAKDDATLS GKRMQSLSLN
   181  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 98 nTPM
tongue: 56 nTPM
choroid plexus: 38 nTPM
heart muscle: 37 nTPM
esophagus: 34 nTPM
colon: 30 nTPM

Single-cell type

esophageal suprabasal cells: 310 nCPM
esophageal basal cells: 307 nCPM
esophageal apical cells: 293 nCPM
extravillous trophoblasts: 255 nCPM
cytotrophoblasts: 252 nCPM
migrating cytotrophoblasts: 249 nCPM

Immune cell

neutrophil: 33 nTPM
NK-cell: 28 nTPM
plasmacytoid DC: 21 nTPM
T-reg: 21 nTPM
intermediate monocyte: 17 nTPM
memory B-cell: 16 nTPM

Brain region

midbrain: 36 nTPM
spinal cord: 35 nTPM
pons: 35 nTPM
medulla oblongata: 34 nTPM
thalamus: 34 nTPM
white matter: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.05
gnomAD missense Z: 1.37
DepMap mean gene effect: -0.8
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Casein kinase substrate, phosphoprotein PP28
28kDa heat- and acid-stable phosphoprotein
Casein kinase substrate phosphoprotein PP28

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RPS11

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDAP1 as an antibody target. Whether an autoantibody or antibody against PDAP1 could matter depends on whether native PDAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDAP1 is annotated at the cell surface, where native PDAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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