Seroatlas · Human Serome Atlas

RPSA

Small ribosomal subunit protein uS2

Also known as: 37LRP, LAMR1, LRP, p40, RSSA_HUMAN, SA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08865
Gene
RPSA
Ensembl
ENSG00000168028
Chromosome
3
Canonical length
295 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>P08865|RPSA
     1  MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL
    61  AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR
   121  LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR
   181  EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA
   241  TQPEVADWSE GVQVPSVPIQ QFPTEDWSAQ PATEDWSAAP TAQATEWVGA TTDWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPSA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
2,518 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 2,518 nTPM
  • ovary: 2,074 nTPM
  • esophagus: 1,840 nTPM
  • spleen: 1,455 nTPM
  • skin: 1,446 nTPM
  • bone marrow: 1,441 nTPM

Single-cell type

  • extravillous trophoblasts: 4,805 nCPM
  • esophageal basal cells: 4,756 nCPM
  • esophageal suprabasal cells: 4,638 nCPM
  • migrating cytotrophoblasts: 4,135 nCPM
  • decidual stromal cells: 3,292 nCPM
  • cytotrophoblasts: 3,068 nCPM

Immune cell

  • total PBMC: 1,548 nTPM
  • naive CD4 T-cell: 1,087 nTPM
  • memory B-cell: 1,046 nTPM
  • MAIT T-cell: 1,030 nTPM
  • memory CD4 T-cell: 989 nTPM
  • naive CD8 T-cell: 978 nTPM

Brain region

  • spinal cord: 408 nTPM
  • thalamus: 385 nTPM
  • white matter: 351 nTPM
  • basal ganglia: 347 nTPM
  • medulla oblongata: 346 nTPM
  • amygdala: 330 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPSA.

Disease | AllUniProt

Conditions RPSA is implicated in, by any mechanism.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 184 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Familial isolated congenital asplenia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.93
gnomAD missense Z
2.42

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPSA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPSA as an antibody target. Whether an autoantibody or antibody against RPSA could matter depends on whether native RPSA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPSA is annotated at the cell surface, where native RPSA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RPSA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPSA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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