Seroatlas · Human Serome Atlas

RPS7

Small ribosomal subunit protein eS7

Also known as: eS7, RS7_HUMAN, S7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62081
Gene
RPS7
Ensembl
ENSG00000171863
Chromosome
2
Canonical length
194 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>P62081|RPS7
     1  MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI
    61  IIFVPVPQLK SFQKIQVRLV RELEKKFSGK HVVFIAQRRI LPKPTRKSRT KNKQKRPRSR
   121  TLTAVHDAIL EDLVFPSEIV GKRIRVKLDG SRLIKVHLDK AQQNNVEHKV ETFSGVYKKL
   181  TGKDVNFEFP EFQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
2,865 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2,865 nTPM
  • breast: 2,050 nTPM
  • bone marrow: 2,029 nTPM
  • pancreas: 1,899 nTPM
  • tonsil: 1,723 nTPM
  • skin: 1,634 nTPM

Single-cell type

  • extravillous trophoblasts: 6,732 nCPM
  • esophageal suprabasal cells: 6,348 nCPM
  • esophageal basal cells: 5,852 nCPM
  • decidual stromal cells: 5,680 nCPM
  • migrating cytotrophoblasts: 5,146 nCPM
  • gastric progenitor cells: 4,949 nCPM

Immune cell

  • total PBMC: 2,068 nTPM
  • memory B-cell: 1,417 nTPM
  • naive CD4 T-cell: 1,259 nTPM
  • MAIT T-cell: 1,195 nTPM
  • naive B-cell: 1,177 nTPM
  • memory CD4 T-cell: 1,163 nTPM

Brain region

  • spinal cord: 300 nTPM
  • choroid plexus: 284 nTPM
  • thalamus: 281 nTPM
  • white matter: 280 nTPM
  • medulla oblongata: 253 nTPM
  • basal ganglia: 253 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS7.

Disease | AllUniProt

Conditions RPS7 is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 236 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.95
gnomAD missense Z
1.63
DepMap mean gene effect
-2.11
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small ribosomal subunit protein eS7
  • Small ribosomal subunit protein eS7, conserved site
  • Ribosomal protein S7e

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS7 as an antibody target. Whether an autoantibody or antibody against RPS7 could matter depends on whether native RPS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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