Seroatlas · Human Serome Atlas

COG2

Conserved oligomeric Golgi complex subunit 2

Also known as: COG2_HUMAN, LDLC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14746
Gene
COG2
Ensembl
ENSG00000135775
Chromosome
1
Canonical length
738 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

738 residues, UniProt reviewed canonical sequence.

>Q14746|COG2
     1  MEKSRMNLPK GPDTLCFDKD EFMKEDFDVD HFVSDCRKRV QLEELRDDLE LYYKLLKTAM
    61  VELINKDYAD FVNLSTNLVG MDKALNQLSV PLGQLREEVL SLRSSVSEGI RAVDERMSKQ
   121  EDIRKKKMCV LRLIQVIRSV EKIEKILNSQ SSKETSALEA SSPLLTGQIL ERIATEFNQL
   181  QFHAVQSKGM PLLDKVRPRI AGITAMLQQS LEGLLLEGLQ TSDVDIIRHC LRTYATIDKT
   241  RDAEALVGQV LVKPYIDEVI IEQFVESHPN GLQVMYNKLL EFVPHHCRLL REVTGGAISS
   301  EKGNTVPGYD FLVNSVWPQI VQGLEEKLPS LFNPGNPDAF HEKYTISMDF VRRLERQCGS
   361  QASVKRLRAH PAYHSFNKKW NLPVYFQIRF REIAGSLEAA LTDVLEDAPA ESPYCLLASH
   421  RTWSSLRRCW SDEMFLPLLV HRLWRLTLQI LARYSVFVNE LSLRPISNES PKEIKKPLVT
   481  GSKEPSITQG NTEDQGSGPS ETKPVVSISR TQLVYVVADL DKLQEQLPEL LEIIKPKLEM
   541  IGFKNFSSIS AALEDSQSSF SACVPSLSSK IIQDLSDSCF GFLKSALEVP RLYRRTNKEV
   601  PTTASSYVDS ALKPLFQLQS GHKDKLKQAI IQQWLEGTLS ESTHKYYETV SDVLNSVKKM
   661  EESLKRLKQA RKTTPANPVG PSGGMSDDDK IRLQLALDVE YLGEQIQKLG LQASDIKSFS
   721  ALAELVAAAK DQATAEQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 67 nTPM
  • rectum: 21 nTPM
  • adrenal gland: 20 nTPM
  • skeletal muscle: 19 nTPM
  • tongue: 19 nTPM
  • colon: 18 nTPM

Single-cell type

  • adrenal cortex cells: 71 nCPM
  • goblet cells: 59 nCPM
  • retinal horizontal cells: 48 nCPM
  • mast cells: 47 nCPM
  • tuft cells: 46 nCPM
  • rod photoreceptor cells: 45 nCPM

Immune cell

  • non-classical monocyte: 30 nTPM
  • NK-cell: 23 nTPM
  • naive CD4 T-cell: 22 nTPM
  • eosinophil: 21 nTPM
  • intermediate monocyte: 19 nTPM
  • naive CD8 T-cell: 19 nTPM

Brain region

  • cerebellum: 19 nTPM
  • choroid plexus: 16 nTPM
  • white matter: 13 nTPM
  • cerebral cortex: 13 nTPM
  • basal ganglia: 12 nTPM
  • thalamus: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COG2.

Disease | AllUniProt

Conditions COG2 is implicated in, by any mechanism.

  • Congenital disorder of glycosylation 2Q (CDG2Q) MIM:617395

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 303 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital disorder of glycosylation, type IIq
  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
-0.49
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • COG complex component, COG2
  • Conserved oligomeric Golgi complex, subunit 2, N-terminal
  • COG complex component, COG2, C-terminal
  • COG2 N-terminal
  • COG complex component, COG2, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COG2 as an antibody target. Whether an autoantibody or antibody against COG2 could matter depends on whether native COG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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