Seroatlas · Human Serome Atlas

RNF157

E3 ubiquitin ligase RNF157

Also known as: KIAA1917, RN157_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PX1
Gene
RNF157
Ensembl
ENSG00000141576
Chromosome
17
Canonical length
679 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process; positive regulation of dendrite extension; and protein ubiquitination. Predicted to be located in cell body. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

679 residues, UniProt reviewed canonical sequence.

>Q96PX1|RNF157
     1  MGALTSRQHA GVEEVDIPSN SVYRYPPKSG SYFASHFIMG GEKFDSTHPE GYLFGENSDL
    61  NFLGNRPVVF PYAAPPPQEP VKTLRSLVNI RKDTLRLVKC AEEVKSPGEE ASKAKVHYNV
   121  EFTFDTDARV AITIYYQATE EFQNGIASYI PKDNSLQSET VQYKRGVCQQ FCLPSHTVDP
   181  SEWAEEELGF DLDREVYPLV VHAVVDEGDE YFGHCHVLLG TFEKHTDGTF CVKPLKQKQV
   241  VDGVSYLLQE IYGIENKYNT QDSKVAEDEV SDNSAECVVC LSDVRDTLIL PCRHLCLCNT
   301  CADTLRYQAN NCPICRLPFR ALLQIRAMRK KLGPLSPTSF NPIISSQTSD SEEHPSSENI
   361  PPGYEVVSLL EALNGPLTPS PAVPPLHVLG DGHLSGMLPS YGSDGHLPPV RTISPLDRLS
   421  DSSSQGLKLK KSLSKSTSQN SSVLHEEEDE HSCSESETQL SQRPSVQHLG EECGVTPESE
   481  NLTLSSSGAI DQSSCTGTPL SSTISSPEGP ASSSLAQSVM SMASSQISTD TVSSMSGSYI
   541  APGTEEEGEA LSSPQPASRA PSEEGEGLPA ESPDSNFAGL PAGEQDAEGN DVIEEEDGSP
   601  TQEGQRTCAF LGMECDNNND FDIASVKALD NKLCSEVCLP GAWQADDNAV SRNAQRRRLS
   661  SSSLEDSETR PCVWGPLAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF157 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 74 nTPM
  • skeletal muscle: 69 nTPM
  • hippocampal formation: 60 nTPM
  • retina: 55 nTPM
  • amygdala: 47 nTPM
  • tongue: 41 nTPM

Single-cell type

  • retinal horizontal cells: 307 nCPM
  • cone photoreceptor cells: 236 nCPM
  • retinal ganglion cells: 189 nCPM
  • retinal bipolar cells: 176 nCPM
  • retinal amacrine cells: 131 nCPM
  • rod photoreceptor cells: 102 nCPM

Immune cell

  • naive CD4 T-cell: 5.8 nTPM
  • naive CD8 T-cell: 3.9 nTPM
  • MAIT T-cell: 3.4 nTPM
  • memory CD4 T-cell: 3.4 nTPM
  • memory CD8 T-cell: 2.7 nTPM
  • basophil: 2.1 nTPM

Brain region

  • cerebral cortex: 188 nTPM
  • pons: 136 nTPM
  • hippocampal formation: 127 nTPM
  • white matter: 127 nTPM
  • medulla oblongata: 122 nTPM
  • thalamus: 117 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF157.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 120 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.81
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF157 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF157 as an antibody target. Whether an autoantibody or antibody against RNF157 could matter depends on whether native RNF157 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF157 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF157 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF157. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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