Seroatlas · Human Serome Atlas

TIPRL

TIP41-like protein

Also known as: dJ69E11.3, MGC3794, TIP41, TIPRL_HUMAN, TIPRL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75663
Gene: TIPRL
Ensembl: ENSG00000143155
Chromosome: 1
Canonical length: 272 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>O75663|TIPRL
     1  MMIHGFQSSH RDFCFGPWKL TASKTHIMKS ADVEKLADEL HMPSLPEMMF GDNVLRIQHG
    61  SGFGIEFNAT DALRCVNNYQ GMLKVACAEE WQESRTEGEH SKEVIKPYDW TYTTDYKGTL
   121  LGESLKLKVV PTTDHIDTEK LKAREQIKFF EEVLLFEDEL HDHGVSSLSV KIRVMPSSFF
   181  LLLRFFLRID GVLIRMNDTR LYHEADKTYM LREYTSRESK ISSLMHVPPS LFTEPNEISQ
   241  YLPIKEAVCE KLIFPERIDP NPADSQKSTQ VE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIPRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 32 nTPM
thymus: 28 nTPM
parathyroid gland: 26 nTPM
skeletal muscle: 23 nTPM
heart muscle: 22 nTPM
endometrium: 22 nTPM

Single-cell type

early primary spermatocytes: 155 nCPM
esophageal apical cells: 145 nCPM
late primary spermatocytes: 143 nCPM
esophageal suprabasal cells: 117 nCPM
esophageal basal cells: 100 nCPM
hofbauer cells: 85 nCPM

Immune cell

basophil: 71 nTPM
eosinophil: 37 nTPM
T-reg: 36 nTPM
neutrophil: 35 nTPM
non-classical monocyte: 34 nTPM
intermediate monocyte: 32 nTPM

Brain region

cerebral cortex: 34 nTPM
hypothalamus: 29 nTPM
basal ganglia: 28 nTPM
hippocampal formation: 27 nTPM
white matter: 25 nTPM
cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.95
gnomAD missense Z: 1.8
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

TIP41-like protein
Phosphatase regulators and Met sulfoxide reductases
TIP41-like family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIPRL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIPRL as an antibody target. Whether an autoantibody or antibody against TIPRL could matter depends on whether native TIPRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIPRL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIPRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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