Seroatlas · Human Serome Atlas

FAM110C

Protein FAM110C

Also known as: F110C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q1W6H9
Gene: FAM110C
Ensembl: ENSG00000184731
Chromosome: 2
Canonical length: 321 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables alpha-tubulin binding activity. Involved in positive regulation of cell migration; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of cell projection assembly. Located in cell cortex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q1W6H9|FAM110C
     1  MRALAALSAP PNERLLPRDP AATRDPDAAR PARRSAVERL AADRAKYVRG RPGTGRGVAS
    61  EGSGPGAIKC PGNDPGPPAR APAPVARRAI ARKPLRPDSL IIYRQKCEFV RGSGADGPRA
   121  SLVKKLFQGP GKDKAPVPRT GDEGKAGNPE TVPTTPGPAA DPAIPETPAP AARSAAPSSV
   181  PAAPPGPEPR VVRRRGLQRS QSDLSSRYSA ALAESDTFFQ YCGLDPEVVE ALGRENFTAG
   241  SDCVTLKVRS VSVATSGSGF SRHSGGDDEG LQEEELIEQV PSTTSVIERN ARIIKWLYTC
   301  KKAKETPSQE QSRTRGSKPS R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM110C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

esophagus: 30 nTPM
epididymis: 20 nTPM
seminal vesicle: 19 nTPM
liver: 16 nTPM
vagina: 15 nTPM
pancreas: 13 nTPM

Single-cell type

epididymal basal cells: 327 nCPM
esophageal apical cells: 262 nCPM
endometrial luminal cells: 250 nCPM
ocular epithelial cells: 210 nCPM
endometrial glandular cells: 140 nCPM
urothelial cells: 132 nCPM

Immune cell

T-reg: 0.4 nTPM
basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 9.2 nTPM
basal ganglia: 9.1 nTPM
cerebral cortex: 7.6 nTPM
white matter: 5.8 nTPM
amygdala: 5.2 nTPM
hippocampal formation: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

alpha-tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM110C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM110C as an antibody target. Whether an autoantibody or antibody against FAM110C could matter depends on whether native FAM110C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM110C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM110C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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