Seroatlas · Human Serome Atlas

CRTC3

CREB-regulated transcription coactivator 3

Also known as: CRTC3_HUMAN, FLJ21868

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UUV7
Gene
CRTC3
Ensembl
ENSG00000140577
Chromosome
15
Canonical length
619 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q6UUV7|CRTC3
     1  MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL QQLRLTQYHG
    61  GSLPNVSQLR SSASEFQPSF HQADNVRGTR HHGLVERPSR NRFHPLHRRS GDKPGRQFDG
   121  SAFGANYSSQ PLDESWPRQQ PPWKDEKHPG FRLTSALNRT NSDSALHTSA LSTKPQDPYG
   181  GGGQSAWPAP YMGFCDGENN GHGEVASFPG PLKEENLLNV PKPLPKQLWE TKEIQSLSGR
   241  PRSCDVGGGN AFPHNGQNLG LSPFLGTLNT GGSLPDLTNL HYSTPLPASL DTTDHHFGSM
   301  SVGNSVNNIP AAMTHLGIRS SSGLQSSRSN PSIQATLNKT VLSSSLNNHP QTSVPNASAL
   361  HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE AHQGFSRQLS STSPLAPYPT
   421  SQMVSSDRSQ LSFLPTEAQA QVSPPPPYPA PQELTQPLLQ QPRAPEAPAQ QPQAASSLPQ
   481  SDFQLLPAQG SSLTNFFPDV GFDQQSMRPG PAFPQQVPLV QQGSRELQDS FHLRPSPYSN
   541  CGSLPNTILP EDSSTSLFKD LNSALAGLPE VSLNVDTPFP LEEELQIEPL SLDGLNMLSD
   601  SSMGLLDPSV EETFRADRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRTC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 38 nTPM
  • ovary: 31 nTPM
  • smooth muscle: 19 nTPM
  • adipose tissue: 18 nTPM
  • endometrium: 18 nTPM
  • colon: 17 nTPM

Single-cell type

  • sertoli cells: 250 nCPM
  • vascular smooth muscle cells: 202 nCPM
  • oligodendrocytes: 202 nCPM
  • adipocytes: 180 nCPM
  • myonuclei: 173 nCPM
  • rod photoreceptor cells: 169 nCPM

Immune cell

  • basophil: 14 nTPM
  • naive CD4 T-cell: 5.5 nTPM
  • naive B-cell: 4.7 nTPM
  • memory CD4 T-cell: 4.1 nTPM
  • T-reg: 3.7 nTPM
  • MAIT T-cell: 3.6 nTPM

Brain region

  • white matter: 52 nTPM
  • basal ganglia: 42 nTPM
  • midbrain: 39 nTPM
  • thalamus: 38 nTPM
  • medulla oblongata: 38 nTPM
  • cerebellum: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.87
gnomAD missense Z
0.4
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRTC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRTC3 as an antibody target. Whether an autoantibody or antibody against CRTC3 could matter depends on whether native CRTC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRTC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRTC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRTC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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