Seroatlas · Human Serome Atlas

CCDC6

Coiled-coil domain-containing protein 6

Also known as: CCDC6_HUMAN, D10S170, H4, PTC, TPC, TST1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16204
Gene
CCDC6
Ensembl
ENSG00000108091
Chromosome
10
Canonical length
474 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q16204|CCDC6
     1  MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV ISPFRLEELT
    61  NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT IQARAEQEEE FISNTLFKKI
   121  QALQKEKETL AVNYEKEEEF LTNELSRKLM QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK
   181  LENDTISKQL TLEQLRREKI DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS
   241  APPSPRDISM EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE
   301  NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV SSPIPYTPSP
   361  SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV QHMGTSHGIT RPSPRRSNSP
   421  DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ PTVPSAATSQ PTPSQHSAHP SSQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 32 nTPM
  • smooth muscle: 29 nTPM
  • salivary gland: 27 nTPM
  • skin: 27 nTPM
  • blood vessel: 26 nTPM
  • basal ganglia: 25 nTPM

Single-cell type

  • esophageal apical cells: 376 nCPM
  • alveolar cells type 1: 321 nCPM
  • lacrimal acinar cells: 303 nCPM
  • endometrial luminal cells: 275 nCPM
  • salivary acinar cells: 247 nCPM
  • salivary duct cells: 201 nCPM

Immune cell

  • myeloid DC: 5 nTPM
  • naive B-cell: 4.9 nTPM
  • memory B-cell: 4.4 nTPM
  • intermediate monocyte: 2.3 nTPM
  • classical monocyte: 2 nTPM
  • memory CD4 T-cell: 1.5 nTPM

Brain region

  • hippocampal formation: 59 nTPM
  • basal ganglia: 56 nTPM
  • hypothalamus: 52 nTPM
  • amygdala: 50 nTPM
  • cerebral cortex: 50 nTPM
  • pons: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC6.

Disease | ImmuneIEDB

Conditions an epitope on CCDC6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.58
gnomAD missense Z
2.81
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF2046
  • Uncharacterized conserved protein H4 (DUF2046)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC6 as an antibody target. Whether an autoantibody or antibody against CCDC6 could matter depends on whether native CCDC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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